Title:
PHOTONIC CRYSTAL MICROSCOPE AND CELL MECHANICS MEASUREMENT METHOD
Document Type and Number:
WIPO Patent Application WO/2022/052361
Kind Code:
A1
Abstract:
A photonic crystal microscope (100) and a cell mechanics measurement method. The photonic crystal microscope (100) comprises a photonic crystal substrate (110), a stage (120), a detection light source (130), and an imaging assembly (140); the photonic crystal substrate (110) is above the stage (120); the detection light source (130) and the imaging assembly (140) are sequentially located on the side of the stage (120) away from the photonic crystal substrate (110); the photonic crystal substrate (110) is used for culturing a cell to be measured, and when said cell grows on the photonic crystal substrate (110), the photonic crystal substrate (110) can deform; the detection light source (130) is used for emitting detection light to the photonic crystal substrate (110); the photonic crystal substrate (110) reflects the detection light to the imaging assembly (140); and the imaging assembly (140) receives the reflected light from the photonic crystal substrate (110) for imaging, so as to obtain acting force information between said cell and the photonic crystal substrate (110) by using the formed image. On the premise of ensuring subcellular measurement precision, the present invention greatly improves flux, simplifies algorithm complexity, improves time resolutions, and reduces device costs and experiment complexity.
Inventors:
GU ZHONGZE (CN)
LI QIWEI (CN)
CHEN ZAOZAO (CN)
LI QIWEI (CN)
CHEN ZAOZAO (CN)
Application Number:
PCT/CN2020/137819
Publication Date:
March 17, 2022
Filing Date:
December 19, 2020
Export Citation:
Assignee:
INSTITUTE OF MEDICAL DEVICES SUZHOU SOUTHEAST UNIV (CN)
International Classes:
G01N21/84; G01N21/01; G02B21/02; G02B21/06; G02B21/34
Foreign References:
| CN111812095A | 2020-10-23 | |||
| CN109827928A | 2019-05-31 | |||
| CN102533537A | 2012-07-04 | |||
| CN105738254A | 2016-07-06 | |||
| US20130230879A1 | 2013-09-05 |
Attorney, Agent or Firm:
BEIJING ZZFY INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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