Title:
PEMETREXED NEAR-INFRARED FLUORESCENT MOLECULE TARGETING α-TYPE FOLATE RECEPTOR, PREPARATION METHOD THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/051308
Kind Code:
A1
Abstract:
Disclosed are a pemetrexed near-infrared fluorescent molecule targeting an α-type folate receptor, a preparation method therefor, and use thereof. The structural formula of the pemetrexed near-infrared fluorescent molecule is: . The pemetrexed near-infrared fluorescent molecule targeting the α-type folate receptor can be applied to the preparation of a drug for treating non-small cell lung cancer. By means of the comparison of the efficacy on non-small cell lung cancer between the clinically approved non-small cell lung cancer chemotherapeutic drug pemetrexed and the novel pemetrexed near-infrared fluorescent molecule, it is found that compared with pemetrexed, the novel pemetrexed near-infrared fluorescent molecule has a three-fold increase in the growth inhibition effect on non-small cell lung cancer, and shows a significant difference in inhibiting tumor tissue growth. Meanwhile, the design strategy of the molecule is to combine the obtained clinically approved therapeutic agents, so that the molecule has good druggability and biological safety.
Inventors:
CAI HUIMING (CN)
WANG YIQING (CN)
LI YUNLONG (CN)
WANG YIQING (CN)
LI YUNLONG (CN)
Application Number:
PCT/CN2023/103821
Publication Date:
March 14, 2024
Filing Date:
June 29, 2023
Export Citation:
Assignee:
NANJING NUOYUAN MEDICAL DEVICES CO LTD (CN)
International Classes:
C07D487/04; A61K31/519; A61P35/00; C09K11/06
Foreign References:
| CN115504984A | 2022-12-23 | |||
| CN115626928A | 2023-01-20 | |||
| CN112010862A | 2020-12-01 | |||
| CN105228628A | 2016-01-06 | |||
| CN111363007A | 2020-07-03 | |||
| CN113150774A | 2021-07-23 | |||
| CN113185498A | 2021-07-30 | |||
| CN114751907A | 2022-07-15 |
Attorney, Agent or Firm:
NANJING XINZHONGHE PATENT AGENCY (GENERAL PARTNERSHIP) (CN)
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