Title:
ORAL COMPOSITION, SKIN COSMETIC AND HAIR COSMETIC
Document Type and Number:
WIPO Patent Application WO/2022/239837
Kind Code:
A1
Abstract:
In an anti-metabolic syndrome agent, a whitening agent, an anti-aging agent, a hair growth tonic, an anti-inflammatory agent and a liver function-improving agent of the present invention, compounds 1-3 represented by general formula (I) are used as active ingredients. In an oral composition, skin cosmetic and hair cosmetic of the present invention, compounds 1-3 represented by general formula (I) are blended. The present invention can provide an anti-metabolic syndrome agent, a whitening agent, an anti-aging agent, a hair growth tonic, an anti-inflammatory agent and a liver function-improving agent each having excellent functional effects. Moreover, the present invention can provide an oral composition, a skin cosmetic and a hair cosmetic each being suitable for anti-metabolic syndrome, whitening, anti-aging, hair growth, anti-inflammatory and liver function-improving purposes.
Inventors:
NISHITANI YOSUKE (JP)
HAYASHI SHOTA (JP)
OGATA MIYUKI (JP)
HAYASHI SHOTA (JP)
OGATA MIYUKI (JP)
Application Number:
PCT/JP2022/020078
Publication Date:
November 17, 2022
Filing Date:
May 12, 2022
Export Citation:
Assignee:
MARUZEN PHARM CO LTD (JP)
International Classes:
A61K31/192; A61K8/36; A61Q1/02; A61Q5/00; A61Q7/00; A61Q19/02; A61Q19/08
Domestic Patent References:
| WO2014048888A1 | 2014-04-03 |
Foreign References:
| JP2006500378A | 2006-01-05 | |||
| JP2002179516A | 2002-06-26 | |||
| JP2003306408A | 2003-10-28 | |||
| EP1604643A1 | 2005-12-14 | |||
| JP2016079186A | 2016-05-16 | |||
| KR20220036304A | 2022-03-22 |
Other References:
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BIAO CHENG, LIU XINRAN, GONG HAO, HUANG LIANQI, CHEN HONG, ZHANG XIN, LI CHUANZHOU, YANG MUYANG, MA BINGJUN, JIAO LIHUA, ZHENG LIN: "Coffee Components Inhibit Amyloid Formation of Human Islet Amyloid Polypeptide in Vitro: Possible Link between Coffee Consumption and Diabetes Mellitus", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 59, no. 24, 28 December 2011 (2011-12-28), pages 13147 - 13155, XP055051923, ISSN: 00218561, DOI: 10.1021/jf201702h
TAKAHASHI T, MIYAZAWA M: "Tyrosinase inhibitory activities of cinnamic acid analogues", PHARMAZIE, vol. 65, no. 12, 1 December 2010 (2010-12-01), DE , pages 913 - 918, XP093003871, ISSN: 0031-7144, DOI: 10.1691/ph.2010.0654
QIN ZE, ZHANG JIN, CHEN LIANG, LIU SHU-XIANG, ZHAO HAI-FENG, MAO HUI-MIN, ZHANG HONG-YANG, LI DE-FANG: "Anti-inflammatory active components of the roots of Datura metel", JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, vol. 23, no. 4, 3 April 2021 (2021-04-03), CH , pages 392 - 398, XP093003876, ISSN: 1028-6020, DOI: 10.1080/10286020.2020.1739660
RUSSELL WENDY R., LABAT AURÉLIE, SCOBBIE LORRAINE, DUNCAN SYLVIA H.: "Availability of blueberry phenolics for microbial metabolism in the colon and the potential inflammatory implications", MOLECULAR NUTRITION & FOOD RESEARCH, vol. 51, no. 6, 1 June 2007 (2007-06-01), DE , pages 726 - 731, XP093003878, ISSN: 1613-4125, DOI: 10.1002/mnfr.200700022
RUNWAL, L.: "Relative Anti-Inflammatory Activity Studies on a Series of Cinnamic and Dihydro Cinnamic Acids", THE EASTERN PHARMACIST, vol. 38, no. 449, 1 January 1995 (1995-01-01), IN , pages 141 - 143, XP009541078, ISSN: 0012-8872
INAGAKI TETSUYA: "On the Influence of Aromatic Compounds upon the Liver Function", THE JAPANESE JOURNAL OF GASTROENTEROLOGY, vol. 9, no. 2, 1 January 1937 (1937-01-01), Kyoto, JP, pages 108 - 121, XP009541188, ISSN: 0369-4259
LI RUI, XIE LI, LI LEI, CHEN XIAOJIAO, YAO TONG, TIAN YUANXIN, LI QINGPING, WANG KAI, HUANG CHENYANG, LI CUI, LI YIFAN, ZHOU HONGW: "The gut microbial metabolite, 3,4-dihydroxyphenylpropionic acid, alleviates hepatic ischemia/reperfusion injury via mitigation of macrophage pro-inflammatory activity in mice", ACTA PHARMACEUTICA SINICA B, vol. 12, no. 1, 1 January 2022 (2022-01-01), pages 182 - 196, XP093003887, ISSN: 2211-3835, DOI: 10.1016/j.apsb.2021.05.029
BIAO CHENG, LIU XINRAN, GONG HAO, HUANG LIANQI, CHEN HONG, ZHANG XIN, LI CHUANZHOU, YANG MUYANG, MA BINGJUN, JIAO LIHUA, ZHENG LIN: "Coffee Components Inhibit Amyloid Formation of Human Islet Amyloid Polypeptide in Vitro: Possible Link between Coffee Consumption and Diabetes Mellitus", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 59, no. 24, 28 December 2011 (2011-12-28), pages 13147 - 13155, XP055051923, ISSN: 00218561, DOI: 10.1021/jf201702h
TAKAHASHI T, MIYAZAWA M: "Tyrosinase inhibitory activities of cinnamic acid analogues", PHARMAZIE, vol. 65, no. 12, 1 December 2010 (2010-12-01), DE , pages 913 - 918, XP093003871, ISSN: 0031-7144, DOI: 10.1691/ph.2010.0654
QIN ZE, ZHANG JIN, CHEN LIANG, LIU SHU-XIANG, ZHAO HAI-FENG, MAO HUI-MIN, ZHANG HONG-YANG, LI DE-FANG: "Anti-inflammatory active components of the roots of Datura metel", JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, vol. 23, no. 4, 3 April 2021 (2021-04-03), CH , pages 392 - 398, XP093003876, ISSN: 1028-6020, DOI: 10.1080/10286020.2020.1739660
RUSSELL WENDY R., LABAT AURÉLIE, SCOBBIE LORRAINE, DUNCAN SYLVIA H.: "Availability of blueberry phenolics for microbial metabolism in the colon and the potential inflammatory implications", MOLECULAR NUTRITION & FOOD RESEARCH, vol. 51, no. 6, 1 June 2007 (2007-06-01), DE , pages 726 - 731, XP093003878, ISSN: 1613-4125, DOI: 10.1002/mnfr.200700022
RUNWAL, L.: "Relative Anti-Inflammatory Activity Studies on a Series of Cinnamic and Dihydro Cinnamic Acids", THE EASTERN PHARMACIST, vol. 38, no. 449, 1 January 1995 (1995-01-01), IN , pages 141 - 143, XP009541078, ISSN: 0012-8872
INAGAKI TETSUYA: "On the Influence of Aromatic Compounds upon the Liver Function", THE JAPANESE JOURNAL OF GASTROENTEROLOGY, vol. 9, no. 2, 1 January 1937 (1937-01-01), Kyoto, JP, pages 108 - 121, XP009541188, ISSN: 0369-4259
LI RUI, XIE LI, LI LEI, CHEN XIAOJIAO, YAO TONG, TIAN YUANXIN, LI QINGPING, WANG KAI, HUANG CHENYANG, LI CUI, LI YIFAN, ZHOU HONGW: "The gut microbial metabolite, 3,4-dihydroxyphenylpropionic acid, alleviates hepatic ischemia/reperfusion injury via mitigation of macrophage pro-inflammatory activity in mice", ACTA PHARMACEUTICA SINICA B, vol. 12, no. 1, 1 January 2022 (2022-01-01), pages 182 - 196, XP093003887, ISSN: 2211-3835, DOI: 10.1016/j.apsb.2021.05.029
Attorney, Agent or Firm:
HAYAKAWA Yuzi et al. (JP)
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