Title:
NOVEL STEROID 11β-HYDROXYLASE AND METHOD FOR PRODUCING 11β-HYDROXYSTEROID USING SAME
Document Type and Number:
WIPO Patent Application WO/2015/111155
Kind Code:
A1
Abstract:
An 11β-hydroxysteroid such as hydrocortisone is produced using protein (a1), (b1), or (c1). (a1) A protein containing an amino acid sequence of SEQ ID NO: 43. (b1) A protein containing an amino acid sequence in which one or several amino acids have been deleted, substituted, or added in an amino acid sequence of SEQ ID NO: 43, the protein exhibiting steroid 11β-hydroxylase activity. (c1) A protein containing an amino acid sequence having 90% or greater sequence identity with an amino acid sequence of SEQ ID NO: 43, the protein exhibiting steroid 11β-hydroxylase activity.
Inventors:
OGAWA JUN (JP)
KIMURA TAKATOSHI (JP)
YODA NAOFUMI (JP)
YAMAMOTO YASUHITO (JP)
SAKAMOTO TAKESHI (JP)
KIMURA TAKATOSHI (JP)
YODA NAOFUMI (JP)
YAMAMOTO YASUHITO (JP)
SAKAMOTO TAKESHI (JP)
Application Number:
PCT/JP2014/051276
Publication Date:
July 30, 2015
Filing Date:
January 22, 2014
Export Citation:
Assignee:
MITSUBISHI CHEM CORP (JP)
International Classes:
C12N15/09; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/04; C12P33/08
Domestic Patent References:
| WO2010079594A1 | 2010-07-15 |
Foreign References:
| JPS62118897A | 1987-05-30 |
Other References:
KENZI SUZUKI ET AL.: "Purification and properties of cytochrome P-450 catalyzing steroid 11beta-hydroxylation in Curvularia lunata", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1203, 1993, pages 215 - 223, XP023332016
GERD-RUDIGER JANIG ET AL.: "Steroid 11beta-hydroxylation by a fungal microsomal cytochrome P450", THE JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 43, no. 8, 1992, pages 1117 - 1123, XP023549786
GERD-RUDIGER JANIG ET AL.: "Steroid 11beta-hydroxylation by a fungal microsomal cytochrome P450", THE JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 43, no. 8, 1992, pages 1117 - 1123, XP023549786
Attorney, Agent or Firm:
KAWAGUCHI, Yoshiyuki et al. (JP)
Yoshiyuki Kawaguchi (JP)
Yoshiyuki Kawaguchi (JP)
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