Title:
NOVEL COMPOUND, AND COMPOSITION FOR PREVENTING OR TREATING HER2-POSITIVE CANCER, COMPRISING SAME
Document Type and Number:
WIPO Patent Application WO/2024/035085
Kind Code:
A1
Abstract:
The present invention relates to a novel compound, and a composition for preventing or treating HER2-positive cancer, comprising same. The novel compound of the present invention can suppress the level of HER2 by inhibiting the protein-protein interaction between ELF3 and MED23, and thereby has a significant anticancer effect. Moreover, even in cases of resistance to trastuzumab, which is conventionally used clinically as a cancer treatment, treatment with the novel compound of the present invention showed a remarkable level of anticancer efficacy. Therefore, it is expected that the novel compound of the present invention can be widely used in the field of cancer treatment.
Inventors:
KWON YOUNGJOO (KR)
HWANG SOO YEON (KR)
NA YOUNGHWA (KR)
HWANG SOO YEON (KR)
NA YOUNGHWA (KR)
Application Number:
PCT/KR2023/011697
Publication Date:
February 15, 2024
Filing Date:
August 08, 2023
Export Citation:
Assignee:
UNIV EWHA IND COLLABORATION (KR)
UNIV CHA IND ACAD COOP FOUND (KR)
UNIV CHA IND ACAD COOP FOUND (KR)
International Classes:
C07D307/40; A61K31/12; A61K31/341; A61K31/381; A61K31/415; A61K31/4155; A61P35/00; C07D231/06; C07D333/06; C07D405/04
Foreign References:
| KR20150025601A | 2015-03-11 | |||
| KR101655697B1 | 2016-09-08 |
Other References:
JIMI M. ALEX; SANDEEP SINGH; RAJ KUMAR: "1‐Acetyl‐3,5‐diaryl‐4,5‐dihydro(1H)pyrazoles: Exhibiting Anticancer Activity through Intracellular ROS Scavenging and the Mitochondria‐Dependent Death Pathway", ARCHIV DER PHARMAZIE, WILEY VERLAG, WEINHEIM, vol. 347, no. 10, 19 August 2014 (2014-08-19), Weinheim , pages 717 - 727, XP071648140, ISSN: 0365-6233, DOI: 10.1002/ardp.201400199
SHASTRI R A: "SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NOVEL PYRAZOLINE AND FLAVONE DERIVATIVES DERIVED FROM FURAN CHALCONES", WORLD JOURNAL OF PHARMACEUTICAL RESEARCH, WORLD JOURNAL OF PHARMACEUTICAL RESEARCH, IN, vol. 4, no. 7, 1 January 2015 (2015-01-01), IN , pages 642 - 651, XP093137163, ISSN: 2277-7105
LÉVAI ALBERT, JEKO JÓZSEF: "Synthesis of hydroxylated 3,5-diaryl-2-pyrazolines by the reaction of hydroxychalcones with hydrazines", ARKIVOC, ARKAT USA, INC., US, vol. 2005, no. 10, 1 January 2005 (2005-01-01), US , pages 199 - 205, XP093137166, ISSN: 1424-6376, DOI: 10.3998/ark.5550190.0006.a17
SHASTRI R A: "SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NOVEL PYRAZOLINE AND FLAVONE DERIVATIVES DERIVED FROM FURAN CHALCONES", WORLD JOURNAL OF PHARMACEUTICAL RESEARCH, WORLD JOURNAL OF PHARMACEUTICAL RESEARCH, IN, vol. 4, no. 7, 1 January 2015 (2015-01-01), IN , pages 642 - 651, XP093137163, ISSN: 2277-7105
LÉVAI ALBERT, JEKO JÓZSEF: "Synthesis of hydroxylated 3,5-diaryl-2-pyrazolines by the reaction of hydroxychalcones with hydrazines", ARKIVOC, ARKAT USA, INC., US, vol. 2005, no. 10, 1 January 2005 (2005-01-01), US , pages 199 - 205, XP093137166, ISSN: 1424-6376, DOI: 10.3998/ark.5550190.0006.a17
Attorney, Agent or Firm:
Y.P.LEE, MOCK & PARTNERS (KR)
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