Title:
NON-IMMUNOGENIC CIRCULAR, NON-VIRAL DNA VECTORS
Document Type and Number:
WIPO Patent Application WO/2024/020320
Kind Code:
A3
Abstract:
The present disclosure relates to circular, non-viral DNA vectors, compositions including one or more of the disclosed vectors, and methods for delivering and/or expressing one or more therapeutic genes (e.g., proteins) in mammals, e.g., human patients. In some embodiments, the present disclosure is directed to circular, non-viral DNA vectors, such as circular non-viral DNA vectors including at least two inverted repeat sequences, where the at least two inverted repeat sequences are separated by a non-repeated nucleotide sequence which is not part of the at least two inverted repeat sequences. In some embodiments, the disclosed circular, non-viral DNA vectors do not include a "DD element." In some embodiments, the disclosed circular, non-viral DNA vectors do not include a "DD element," but include at least a portion of a bacterial origin of replication.
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Inventors:
BARTLETT JEFFREY S (US)
YAN MING (US)
YAN MING (US)
Application Number:
PCT/US2023/070238
Publication Date:
April 25, 2024
Filing Date:
July 14, 2023
Export Citation:
Assignee:
RAMPART BIOSCIENCE INC (US)
International Classes:
C12N15/85; A61K38/00; A61K48/00; C12N9/16; A61P19/00
Attorney, Agent or Firm:
FINETTI, Thomas (US)
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