Title:
NCGL2747 GENE MUTANT AND USE THEREOF IN PREPARATION OF L-LYSINE
Document Type and Number:
WIPO Patent Application WO/2023/231547
Kind Code:
A1
Abstract:
Provided are an NCgl2747 gene mutant and the use thereof in the preparation of L-lysine. The NCgl2747 gene mutant is a DNA molecule shown in SEQ ID No.3, which encodes the NCgl2747 mutant protein shown in SEQ ID No.4. Mutating the NCgl2747 gene into the NCgl2747 gene mutant shown in SEQ ID No.3 or overexpressing NCgl2747 gene mutant contributes to increase in the yield and the growth rate of L-lysine. However, when the gene is weakened or knocked out, accumulation of the L-lysine is not facilitated, and the growth rate of a strain can be reduced. The NCgl2747 gene mutant and the NCgl2747 mutant protein encoded thereby can be used for preparing L-lysine.
Inventors:
MENG GANG (CN)
ZHOU XIAOQUN (CN)
WEI AIYING (CN)
ZHAO CHUNGUANG (CN)
MA FENGYONG (CN)
MA WENYOU (CN)
ZHOU XIAOQUN (CN)
WEI AIYING (CN)
ZHAO CHUNGUANG (CN)
MA FENGYONG (CN)
MA WENYOU (CN)
Application Number:
PCT/CN2023/084970
Publication Date:
December 07, 2023
Filing Date:
March 30, 2023
Export Citation:
Assignee:
NINGXIA EPPEN BIOTECH CO LTD (CN)
International Classes:
C12N1/21; C07K14/34; C12N15/31; C12N15/77; C12P13/08
Foreign References:
| US20180362991A1 | 2018-12-20 | |||
| CN110869504A | 2020-03-06 | |||
| CN113249286A | 2021-08-13 | |||
| CN110862940A | 2020-03-06 | |||
| US20100151449A1 | 2010-06-17 |
Other References:
DATABASE Protein 30 January 2014 (2014-01-30), ANONYMOUS : "putative aspartate aminotransferase, AT class I [Corynebacterium glutamicum MB001]", XP093116343, retrieved from NCBI Database accession no. AGT06552.1
Attorney, Agent or Firm:
JEEKAI & PARTNERS (CN)
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