Title:
MUTANT OF SMALL MOLECULAR CHAPERONE PROTEIN MOG1-ENCODING GENE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/201851
Kind Code:
A1
Abstract:
Provided are a mutant of a small molecular chaperone protein MOG1-encoding gene and use thereof. The mutant is more effective than a wild-type MOG1 in enhancing myocardial sodium current, and the mutant of the small molecular chaperone protein MOG1-encoding gene and a mutant of the small molecular chaperone protein MOG1 are used in the preparation of medicaments for the treatment of diseases such as Brugada syndrome, arrhythmia, dilated cardiomyopathy, or heart failure.
Inventors:
WANG QING (CN)
XIONG HONGBO (CN)
XIONG HONGBO (CN)
Application Number:
PCT/CN2022/096227
Publication Date:
October 26, 2023
Filing Date:
May 31, 2022
Export Citation:
Assignee:
UNIV HUAZHONG SCIENCE TECH (CN)
International Classes:
C12N15/11; A61P9/00; A61P9/04; A61P9/06
Foreign References:
| CN113416752A | 2021-09-21 | |||
| CN107974498A | 2018-05-01 |
Other References:
LIU, HENG: "The Functional Research of The Human MOG1/RAN Compound in Mitosis And The Preliminary Research of The Structure And Function of The MOG1/RAN RANDBP1 Compound", BASIC SCIENCES, CHINA DOCTORAL DISSERTATIONS FULL-TEXT DATABASE, 15 June 2018 (2018-06-15)
CHAKRABARTI SUSMITA, WU XIAOFEN, YANG ZHAOGANG, WU LING, YONG SANDRO L., ZHANG CUNTAI, HU KELI, WANG QING K., CHEN QIUYUN: "MOG1 Rescues Defective Trafficking of Na v 1.5 Mutations in Brugada Syndrome and Sick Sinus Syndrome", CIRCULATION: ARRHYTHMIA AND ELECTROPHYSIOLOGY, LIPPINCOTT WILLIAMS & WILKINS, UNITED STATES, vol. 6, no. 2, 1 April 2013 (2013-04-01), United States , pages 392 - 401, XP093102920, ISSN: 1941-3149, DOI: 10.1161/CIRCEP.111.000206
DATABASE NUCLEOTIDE ANONYMOUS : "Homo sapiens MOG1 isoform A (MOG1) mRNA, complete cds, alternatively spliced", XP093102924, retrieved from NCBI
CHAKRABARTI SUSMITA, WU XIAOFEN, YANG ZHAOGANG, WU LING, YONG SANDRO L., ZHANG CUNTAI, HU KELI, WANG QING K., CHEN QIUYUN: "MOG1 Rescues Defective Trafficking of Na v 1.5 Mutations in Brugada Syndrome and Sick Sinus Syndrome", CIRCULATION: ARRHYTHMIA AND ELECTROPHYSIOLOGY, LIPPINCOTT WILLIAMS & WILKINS, UNITED STATES, vol. 6, no. 2, 1 April 2013 (2013-04-01), United States , pages 392 - 401, XP093102920, ISSN: 1941-3149, DOI: 10.1161/CIRCEP.111.000206
DATABASE NUCLEOTIDE ANONYMOUS : "Homo sapiens MOG1 isoform A (MOG1) mRNA, complete cds, alternatively spliced", XP093102924, retrieved from NCBI
Attorney, Agent or Firm:
HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY PATENT AGENCY CENTER (CN)
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