Title:
MINIATURIZED, LOW-COST, AND MULTI-CONTRAST UNMARKED MICROSCOPIC IMAGING SYSTEM
Document Type and Number:
WIPO Patent Application WO/2022/062773
Kind Code:
A1
Abstract:
The present invention discloses a miniaturized, low-cost, and multi-contrast unmarked microscopic imaging system. The imaging system is based on an inverted microscopic structure, a highly integrated optical system is designed by adopting a micro lens having a fixed focal length, and a complex optical system of a traditional microscope system is replaced, such that the whole microscope is highly integrated. The system uses a programmable LED array as an illumination light source; the LED array is controlled by a computer to display different illumination modes; six imaging functions of a bright field, a dark field, a rainbow dark field, Rheinberg optical dyeing, differential phase contrast, and quantitative phase imaging are achieved; and diversified unmarked imaging methods are provided for biological applications. The present invention provides a matching control system, which can realize system hardware control and algorithm execution and display, comprises functions such as illumination control, camera parameter adjustment, quantitative phase reconstruction recovery, two-dimensional/three-dimensional result display, and quantitative profile analysis, and can realize diversified information obtaining and analysis of unmarked samples.
Inventors:
CHEN QIAN (CN)
FAN YAO (CN)
ZUO CHAO (CN)
SUN JIASONG (CN)
FENG SHIJIE (CN)
LI JIAJI (CN)
ZHANG JIALIN (CN)
LU LINPENG (CN)
ZHANG RUNNAN (CN)
ZHANG ZEYU (CN)
ZHANG YUZHEN (CN)
FAN YAO (CN)
ZUO CHAO (CN)
SUN JIASONG (CN)
FENG SHIJIE (CN)
LI JIAJI (CN)
ZHANG JIALIN (CN)
LU LINPENG (CN)
ZHANG RUNNAN (CN)
ZHANG ZEYU (CN)
ZHANG YUZHEN (CN)
Application Number:
PCT/CN2021/113185
Publication Date:
March 31, 2022
Filing Date:
August 18, 2021
Export Citation:
Assignee:
UNIV NANJING SCI & TECH (CN)
International Classes:
G02B21/06; G01N21/41; G02B21/10; G02B21/12; G02B21/14
Foreign References:
| CN112130309A | 2020-12-25 | |||
| CN106768396A | 2017-05-31 | |||
| CN109375358A | 2019-02-22 | |||
| CN107272178A | 2017-10-20 | |||
| CN105425377A | 2016-03-23 | |||
| CN107290846A | 2017-10-24 | |||
| CN103197413A | 2013-07-10 |
Other References:
DING JUNYI: "Design and Development of the Built-In Cell Dynamic 3D Microscopic Imaging System of the Incubator", MASTER THESIS, TIANJIN POLYTECHNIC UNIVERSITY, CN, no. 6, 15 June 2020 (2020-06-15), CN , XP055914487, ISSN: 1674-0246
Attorney, Agent or Firm:
JIANGSU SHENGDIAN LAW FIRM (CN)
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