Title:
MICROPHYSIOLOGICAL SYSTEM
Document Type and Number:
WIPO Patent Application WO/2024/096090
Kind Code:
A1
Abstract:
Disclosed is a microphysiological system comprising a microfluidic device, and human renal proximal tubular epithelial cells (RPTEC) and pluripotent stem cell-derived LTL-positive cells which are accommodated in the microfluidic device. The microfluidic device comprises a device body, a first chamber provided to the device body, a second chamber provided to the device body, and a porous membrane which is positioned between the first chamber and the second chamber, and separates the first chamber and the second chamber. The RPTEC and the LTL-positive cells are accommodated inside the first chamber and are attached to a first surface of the porous membrane facing the first chamber.
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Inventors:
YOKOKAWA RYUJI (JP)
RAMIN BANAN SADEGHIAN (JP)
UENO RYOUHEI (JP)
ARAOKA TOSHIKAZU (JP)
TAKASATO MINORU (JP)
SAHARA YOSHIKI (JP)
RAMIN BANAN SADEGHIAN (JP)
UENO RYOUHEI (JP)
ARAOKA TOSHIKAZU (JP)
TAKASATO MINORU (JP)
SAHARA YOSHIKI (JP)
Application Number:
PCT/JP2023/039543
Publication Date:
May 10, 2024
Filing Date:
November 02, 2023
Export Citation:
Assignee:
RIKEN (JP)
International Classes:
C12M3/00; C12M1/00; C12N5/071; C12N5/10; G01N33/15; G01N37/00
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (Marunouchi MY PLAZA 9th fl. 1-1, Marunouchi 2-chome, Chiyoda-k, Tokyo 05, JP)
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