Title:
METHODS AND DEVICES FOR USING AIRFLOW-DRIVEN, EVAPORATIVE GRADIENTS
Document Type and Number:
WIPO Patent Application WO/2023/060006
Kind Code:
A3
Abstract:
Microfluidic paper-based analytical methods and devices are disclosed. In one implementation, a method includes applying a gas flow to a first spot of a porous or fibrous membrane for fluorescent detection assay to generate an enriched substance underneath the first spot in the porous or fibrous membrane, controlling the gas flow such that the enriched substance causes a fluorescent intensity change in the porous or fibrous membrane, and performing a fluorescent detection readout based on the fluorescent intensity change.
Inventors:
LO YU-HWA (US)
WANG EDWARD (US)
GUO ZHILIN (US)
TANG RUI (US)
WANG EDWARD (US)
GUO ZHILIN (US)
TANG RUI (US)
Application Number:
PCT/US2022/077204
Publication Date:
July 13, 2023
Filing Date:
September 28, 2022
Export Citation:
Assignee:
UNIV CALIFORNIA (US)
International Classes:
G01N21/77; G01N21/78; G01N33/50
Foreign References:
| US9709582B1 | 2017-07-18 | |||
| US20070074972A1 | 2007-04-05 | |||
| US10982270B2 | 2021-04-20 | |||
| US20150353919A1 | 2015-12-10 | |||
| US20100186524A1 | 2010-07-29 | |||
| US20040083698A1 | 2004-05-06 | |||
| US8013984B2 | 2011-09-06 | |||
| US20130301047A1 | 2013-11-14 |
Other References:
WANG EDWARD, GUO ZHILIN, TANG RUI, LO YU-HWA: "Using airflow-driven, evaporative gradients to improve sensitivity and fluid control in colorimetric paper-based assays", LAB ON A CHIP, ROYAL SOCIETY OF CHEMISTRY, UK, vol. 21, no. 21, 26 October 2021 (2021-10-26), UK , pages 4249 - 4261, XP093078933, ISSN: 1473-0197, DOI: 10.1039/D1LC00542A
Attorney, Agent or Firm:
TEHRANCHI, Babak et al. (US)
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