Title:
METHOD AND SYSTEM FOR DESIGNING RNA THERAPEUTIC AGENT
Document Type and Number:
WIPO Patent Application WO/2023/229410
Kind Code:
A1
Abstract:
In a method for designing an RNA therapeutic agent, a non-target analysis module receives a target mRNA associated with causing a particular disease and selects mRNAs having gene expression patterns similar to the pattern of the target mRNA as a plurality of non-target mRNAs among plurality of mRNAs in human body, and a base sequence generation module determines the base sequence of an RNA therapeutic agent which greatly inhibits the activity of the target mRNA while minimally inhibiting the activity of the plurality of non-target mRNAs.
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Inventors:
SEO DONG-GIN (KR)
KANG MIN-GEUN (KR)
HWANG GYEONG-JO (KR)
LEE KI-WON (KR)
KANG MIN-GEUN (KR)
HWANG GYEONG-JO (KR)
LEE KI-WON (KR)
Application Number:
PCT/KR2023/007218
Publication Date:
November 30, 2023
Filing Date:
May 25, 2023
Export Citation:
Assignee:
SPIDERCORE INC (KR)
International Classes:
G16B30/10; C12Q1/6869; G06N20/00; G16B20/00; G16B25/10
Foreign References:
| KR102499895B1 | 2023-02-16 |
Other References:
DAR SHOWKAT AHMAD, GUPTA AMIT KUMAR, THAKUR ANAMIKA, KUMAR MANOJ: "SMEpred workbench: A web server for predicting efficacy of chemicallymodified siRNAs", RNA BIOLOGY, vol. 13, no. 11, 1 November 2016 (2016-11-01), pages 1144 - 1151, XP093111205, ISSN: 1547-6286, DOI: 10.1080/15476286.2016.1229733
HUANG YI, FURUNO MASAAKI, ARAKAWA TAKAHIRO, TAKIZAWA SATOSHI, DE HOON MICHIEL, SUZUKI HARUKAZU, ARNER ERIK: "A framework for identification of on- and off-target transcriptional responses to drug treatment", SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, US, vol. 9, no. 1, 26 November 2019 (2019-11-26), US , pages 17603, XP093111206, ISSN: 2045-2322, DOI: 10.1038/s41598-019-54180-4
WHATLEY ALEXANDER, LUO ZHEKUN, TANG XIANGRU: "Improving RNA Secondary Structure Design using Deep Reinforcement Learning", ARXIV (CORNELL UNIVERSITY), CORNELL UNIVERSITY LIBRARY, ARXIV.ORG, ITHACA, 5 November 2021 (2021-11-05), Ithaca, XP093111207, [retrieved on 20231212], DOI: 10.48550/arxiv.2111.04504
SHAKER BILAL; AHMAD SAJJAD; LEE JINGYU; JUNG CHANJIN; NA DOKYUN: "In silico methods and tools for drug discovery", COMPUTERS IN BIOLOGY AND MEDICINE, NEW YORK, NY, US, vol. 137, 8 September 2021 (2021-09-08), US , XP086806860, ISSN: 0010-4825, DOI: 10.1016/j.compbiomed.2021.104851
HUANG YI, FURUNO MASAAKI, ARAKAWA TAKAHIRO, TAKIZAWA SATOSHI, DE HOON MICHIEL, SUZUKI HARUKAZU, ARNER ERIK: "A framework for identification of on- and off-target transcriptional responses to drug treatment", SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, US, vol. 9, no. 1, 26 November 2019 (2019-11-26), US , pages 17603, XP093111206, ISSN: 2045-2322, DOI: 10.1038/s41598-019-54180-4
WHATLEY ALEXANDER, LUO ZHEKUN, TANG XIANGRU: "Improving RNA Secondary Structure Design using Deep Reinforcement Learning", ARXIV (CORNELL UNIVERSITY), CORNELL UNIVERSITY LIBRARY, ARXIV.ORG, ITHACA, 5 November 2021 (2021-11-05), Ithaca, XP093111207, [retrieved on 20231212], DOI: 10.48550/arxiv.2111.04504
SHAKER BILAL; AHMAD SAJJAD; LEE JINGYU; JUNG CHANJIN; NA DOKYUN: "In silico methods and tools for drug discovery", COMPUTERS IN BIOLOGY AND MEDICINE, NEW YORK, NY, US, vol. 137, 8 September 2021 (2021-09-08), US , XP086806860, ISSN: 0010-4825, DOI: 10.1016/j.compbiomed.2021.104851
Attorney, Agent or Firm:
CHOI, Jung-moon (KR)
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