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Title:
METHOD AND SYSTEM FOR CONSTRUCTING DYNAMIC GENE REGULATORY NETWORK, AND COMPUTER DEVICE
Document Type and Number:
WIPO Patent Application WO/2024/077533
Kind Code:
A1
Abstract:
The present invention relates to a method and system for constructing a dynamic gene regulatory network, and a computer device, a computer-readable storage medium, a computer program product, and a computer program. The method comprises: constructing a plurality of single-cell pseudo-time differentiation trajectories on the basis of single-cell transcriptome data of a plurality of single cells; determining a dynamic change gene in a target pseudo-time differentiation trajectory on the basis of the plurality of single-cell pseudo-time differentiation trajectories; constructing an initial static gene interaction network on the basis of the dynamic change gene; and performing inspection on the basis of the initial static gene interaction network to obtain a dynamic gene regulatory network. According to the method, a key gene regulatory mechanism corresponding to cells in different differentiation stages can be quickly determined, and the real dynamic change condition of a gene regulatory relationship in a biological process is reflected.

Inventors:
WEL KUN (CN)
YUAN YONGXIAN (CN)
XIE LU (CN)
ZHU YABING (CN)
Application Number:
PCT/CN2022/124982
Publication Date:
April 18, 2024
Filing Date:
October 12, 2022
Export Citation:
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Assignee:
BGI TECH SOLUTIONS CO LTD (CN)
WUHAN BGI TECH SERVICE CO LTD (CN)
International Classes:
G16B25/10
Foreign References:
CN114360634A2022-04-15
CN111951892A2020-11-17
CN112151117A2020-12-29
US20030219764A12003-11-27
US20200370112A12020-11-26
Attorney, Agent or Firm:
FASHENG INTELLECTUAL PROPERTY COMPANY, LTD. (CN)
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