Title:
METHOD FOR PREPARING DRUG-LINKER CONJUGATE
Document Type and Number:
WIPO Patent Application WO/2023/098515
Kind Code:
A1
Abstract:
Provided in the present application is a method for preparing a drug-linker conjugate. Specifically, provided in the present application is a method for preparing compound IM2, the method comprising the following steps: adding compound SM1 to a mixed solution of triphosgene and 4-dimethylaminopyridine to obtain an intermediate solution; and adding compound SM2 to the intermediate solution, and stirring the mixture to obtain compound IM2. The stability, practicability and scalability of the process are improved by means of optimizing the preparation process of IM2 and switching to the normal phase chromatographic purification that is easy to scale up.
Inventors:
HAN WEIBIAO (CN)
CHEN XING (CN)
SONG YAOYAO (CN)
HUANG ZHONGCHAO (CN)
XIA DONGLIANG (CN)
TAN SHIJIE (CN)
WANG TAO (CN)
LIU ZHIHUAN (CN)
QI HONGXIA (CN)
LIANG YUFENG (CN)
SONG HONGMEI (CN)
GE JUNYOU (CN)
WANG JINGYI (CN)
CHEN XING (CN)
SONG YAOYAO (CN)
HUANG ZHONGCHAO (CN)
XIA DONGLIANG (CN)
TAN SHIJIE (CN)
WANG TAO (CN)
LIU ZHIHUAN (CN)
QI HONGXIA (CN)
LIANG YUFENG (CN)
SONG HONGMEI (CN)
GE JUNYOU (CN)
WANG JINGYI (CN)
Application Number:
PCT/CN2022/133439
Publication Date:
June 08, 2023
Filing Date:
November 22, 2022
Export Citation:
Assignee:
SICHUAN KELUN BIOTECH BIOPHARMACEUTICAL CO LTD (CN)
International Classes:
C07D491/22
Domestic Patent References:
| WO2019114666A1 | 2019-06-20 | |||
| WO2021228141A1 | 2021-11-18 |
Foreign References:
| CN113416217A | 2021-09-21 | |||
| CN110903395A | 2020-03-24 |
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
Download PDF:
Previous Patent: SHOCK ABSORBER
Next Patent: ELECTRONIC REFEREEING SYSTEM AND METHOD FOR BOXING, AND STORAGE MEDIUM
Next Patent: ELECTRONIC REFEREEING SYSTEM AND METHOD FOR BOXING, AND STORAGE MEDIUM