Title:
METHOD FOR PREPARING CHOLINE ALFOSCERATE, USABLE AS FOOD RAW MATERIAL, FROM PHOSPHATIDYLCHOLINE OR LECITHIN
Document Type and Number:
WIPO Patent Application WO/2019/132549
Kind Code:
A1
Abstract:
The present invention relates to a method for preparing choline alfoscerate, usable as a food raw material, from phosphatidylcholine or lecithin, and a choline alfoscerate preparation method according to the present invention uses a specific reaction medium and a specific catalytic enzyme, thereby enabling a high purity choline alfoscerate to be effectively prepared. Particularly, the preparation method allows a mixed solvent of water and hexane, which have high substrate solubility and an extraction solvent usable in the preparation of food raw materials, to be used as a reaction medium, and enables high purity purification of choline alfoscerate by only using a layer separation process of the reaction medium, thereby enhancing the productivity of choline alfoscerate to be greater than that of a conventional enzymatic synthesis method, having, unlike a conventional chemical synthesis method and a conventional purification method, very simple purification, and enabling the preparation of choline alfoscerate which is usable as a food raw material. Specifically, lecithin is a raw material of fractionated lecithin used as a substrate in the preparation method and is an inexpensive raw material obtained as a by-product in a soybean oil refining process and the like, and thus is expected to be greatly helpful in the commercialization of the preparation method in the future. In addition, choline alfoscerate prepared by the method according to the present invention can be effectively usable as a material for foods, pharmaceuticals and the like for improving cognitive function in patients having had a stroke and having dementia such as Alzheimer's disease.
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Inventors:
KIM BYUNG HEE (KR)
KIM JEONG EUN (KR)
LEE JUNG EUN (KR)
SONG YE JIN (KR)
LEE SOO JEONG (KR)
KIM DO HEE (KR)
KIM JEONG EUN (KR)
LEE JUNG EUN (KR)
SONG YE JIN (KR)
LEE SOO JEONG (KR)
KIM DO HEE (KR)
Application Number:
PCT/KR2018/016779
Publication Date:
July 04, 2019
Filing Date:
December 27, 2018
Export Citation:
Assignee:
INDUSTRY ACADEMIC COOPERATION FOUNDATION SOOKMYUNG WOMENS UNIV (KR)
International Classes:
A23L29/00; C12P13/00; A23L33/10; C12N9/20; C12N11/04; C12N11/08; C12P9/00
Foreign References:
| KR20060102880A | 2006-09-28 | |||
| US20050227945A1 | 2005-10-13 | |||
| US20120244583A1 | 2012-09-27 |
Other References:
BANG, HYO-JEONG ET AL.: "Phospholipase A1-catalyzed Hydrolysis of Soy Phosphatidylcholine to Prepare L-alpha-glycerylphosphorylcholine in Organic-aqueous Media", FOOD CHEMISTRY, vol. 190, 2016, pages 201 - 206, XP055624185, [retrieved on 20150520]
BAEZA-JIMENEZ, RAMIRO ET AL.: "Enzyme-catalysed Hydrolysis of Phosphatidylcholine for the Production of Lysophosphatidylcholine", J. CHEM. TECHNOL. BIOTECHNOL., vol. 88, no. 10, 2013, pages 1859 - 1863, XP055624189, [retrieved on 20130307]
BAEZA-JIMENEZ, RAMIRO ET AL.: "Enzyme-catalysed Hydrolysis of Phosphatidylcholine for the Production of Lysophosphatidylcholine", J. CHEM. TECHNOL. BIOTECHNOL., vol. 88, no. 10, 2013, pages 1859 - 1863, XP055624189, [retrieved on 20130307]
Attorney, Agent or Firm:
TAEBAEK INTELLECTUAL PROPERTY LAW FIRM (KR)
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