Title:
METHOD FOR LOCALIZATION OF BLOOD CLOTS
Document Type and Number:
WIPO Patent Application WO2000057787
Kind Code:
A3
Abstract:
A method wherein a radiolabelled compound is localized at a thrombus. Two-dimensional images, representing a physical property associated with the radiolabelled thrombus, are acquired and assembled into a three-dimensional matrix of data. The three-dimensional matrix of data is then scanned along an array of parallel lines to determine a maximum value along each line. The maximum value along each line is then assigned to a pixel in a two-dimensional array, where the relative position of the pixel in the two-dimensional array corresponds to the relative position of the line in the array of parallel lines.
Inventors:
LAZEWATSKY JOEL
Application Number:
PCT/US2000/007891
Publication Date:
February 22, 2001
Filing Date:
March 24, 2000
Export Citation:
Assignee:
DU PONT PHARM CO (US)
International Classes:
A61K51/08; (IPC1-7): A61K51/04; A61K51/08
Domestic Patent References:
| WO1996040637A1 | 1996-12-19 | |||
| WO1996031243A1 | 1996-10-10 | |||
| WO1994022494A1 | 1994-10-13 |
Other References:
EDWARDS D S ET AL: "NEW AND VERSATILE TERNARY LIGAND SYSTEM FOR TECHNETIUM RADIOPHARMACEUTICALS: WATER SOLUBLE PHOSPHINES AND TRICINE AS COLIGANDS IN LABELING A HYDRAZINONICOTINAMIDE-MODIFIED CYCLIC GLYCOPROTEIN IIB/IIIA RECEPTOR ANTAGONIST WITH 99MTC", BIOCONJUGATE CHEMISTRY,US,AMERICAN CHEMICAL SOCIETY, WASHINGTON, vol. 8, no. 2, 1 March 1997 (1997-03-01), pages 146 - 154, XP000682494, ISSN: 1043-1802
RAJOPADHYE M ET AL: "Synthesis, evaluation and Tc-99m complexation of a hydrazinonicotinyl conjugate of a gp IIb/IIIa antagonist cyclic peptide for the detection of deep vein thrombosis", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,GB,OXFORD, vol. 7, no. 8, 22 April 1997 (1997-04-22), pages 955 - 960, XP004136163, ISSN: 0960-894X
BARRETT JOHN A ET AL: "Biological evaluation of thrombus imaging agents utilizing water soluble phosphines and tricine as coligands when used to label a hydrazinonicotinamide-modified cyclic glycoprotein IIb/IIIa receptor antagonist with 99mTc.", BIOCONJUGATE CHEMISTRY, vol. 8, no. 2, 1997, pages 155 - 160, XP002154879, ISSN: 1043-1802
LIU SHUANG ET AL: "Labeling a hydrazino nicotinamide-modified cyclic IIb/IIIa receptor antagonist with 99mTc using aminocarboxylates as coligands.", BIOCONJUGATE CHEMISTRY, vol. 7, no. 1, 1996, pages 63 - 71, XP002154880, ISSN: 1043-1802
HARRIS T D ET AL: "Tc-99m-labeled fibrinogen receptor antagonists: design and synthesis of cyclic RGD peptides for the detection of thrombi", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,GB,OXFORD, vol. 6, no. 15, 6 August 1996 (1996-08-06), pages 1741 - 1746, XP004135594, ISSN: 0960-894X
HOM R K ET AL: "Technetium-99m-Labeled Receptor-Specific Small-Molecule Radiopharmaceuticals: Recent Developments and Encouraging Results", NUCLEAR MEDICINE AND BIOLOGY,US,ELSEVIER SCIENCE PUBLISHERS, NEW YORK, NY, vol. 24, no. 6, 1 August 1997 (1997-08-01), pages 485 - 498, XP004089519, ISSN: 0969-8051
RAJOPADHYE M ET AL: "Synthesis, evaluation and Tc-99m complexation of a hydrazinonicotinyl conjugate of a gp IIb/IIIa antagonist cyclic peptide for the detection of deep vein thrombosis", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,GB,OXFORD, vol. 7, no. 8, 22 April 1997 (1997-04-22), pages 955 - 960, XP004136163, ISSN: 0960-894X
BARRETT JOHN A ET AL: "Biological evaluation of thrombus imaging agents utilizing water soluble phosphines and tricine as coligands when used to label a hydrazinonicotinamide-modified cyclic glycoprotein IIb/IIIa receptor antagonist with 99mTc.", BIOCONJUGATE CHEMISTRY, vol. 8, no. 2, 1997, pages 155 - 160, XP002154879, ISSN: 1043-1802
LIU SHUANG ET AL: "Labeling a hydrazino nicotinamide-modified cyclic IIb/IIIa receptor antagonist with 99mTc using aminocarboxylates as coligands.", BIOCONJUGATE CHEMISTRY, vol. 7, no. 1, 1996, pages 63 - 71, XP002154880, ISSN: 1043-1802
HARRIS T D ET AL: "Tc-99m-labeled fibrinogen receptor antagonists: design and synthesis of cyclic RGD peptides for the detection of thrombi", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,GB,OXFORD, vol. 6, no. 15, 6 August 1996 (1996-08-06), pages 1741 - 1746, XP004135594, ISSN: 0960-894X
HOM R K ET AL: "Technetium-99m-Labeled Receptor-Specific Small-Molecule Radiopharmaceuticals: Recent Developments and Encouraging Results", NUCLEAR MEDICINE AND BIOLOGY,US,ELSEVIER SCIENCE PUBLISHERS, NEW YORK, NY, vol. 24, no. 6, 1 August 1997 (1997-08-01), pages 485 - 498, XP004089519, ISSN: 0969-8051
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