Title:
METHOD FOR GENERATING CELLS OF THE T CELL LINEAGE WITH ENGINEERING BROADLY REACTIVE HUMAN NOTCH LIGAND
Document Type and Number:
WIPO Patent Application WO/2024/036105
Kind Code:
A3
Abstract:
A method of generating cells of the T cell lineage is provided that involves culturing a sample comprising stem cells or progenitor cells with an engineered Notch ligand conjugated to a suspension support and isolating cells of the T cell lineage. In one embodiment, the cells of the T-cell lineage are progenitor T cells or mature T cells. Compositions, kits and uses thereof are also provided.
Inventors:
LUCA VINCENT C (US)
Application Number:
PCT/US2023/071775
Publication Date:
April 25, 2024
Filing Date:
August 07, 2023
Export Citation:
Assignee:
H LEE MOFFITT CANCER CT & RES (US)
International Classes:
A61K35/17; A61K38/17; A61P35/00; C07K14/435; C12N5/0783; C12N15/63; C12N5/074; C12P21/02
Attorney, Agent or Firm:
GILES, Brian, P. (US)
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