Title:
METHOD FOR DETECTING PULMONARY HYPERTENSION AND MEDICATION FOR PREVENTING OR TREATING PULMONARY HYPERTENSION
Document Type and Number:
WIPO Patent Application WO/2024/080377
Kind Code:
A1
Abstract:
The present invention pertains to a method for detecting pulmonary hypertension, the method comprising step (I-1) and step (I-2), in that order. In step (I-1), the content of myosin light chain 9 (Myl9) protein in a biological sample derived from a subject is measured, and in step (I-2), the obtained measurement value of the content of Myl9 protein is compared to a reference value which has been set in advance.
Inventors:
NAKAYAMA TOSHINORI (JP)
KIMURA MOTOKO (JP)
HIRAHARA KIYOSHI (JP)
IWAMURA CHIAKI (JP)
KURIYAMA SACHIKO (JP)
KIMURA MOTOKO (JP)
HIRAHARA KIYOSHI (JP)
IWAMURA CHIAKI (JP)
KURIYAMA SACHIKO (JP)
Application Number:
PCT/JP2023/037289
Publication Date:
April 18, 2024
Filing Date:
October 13, 2023
Export Citation:
Assignee:
UNIV CHIBA NAT UNIV CORP (JP)
JUNTENDO EDUCATIONAL FOUND (JP)
JUNTENDO EDUCATIONAL FOUND (JP)
International Classes:
G01N33/68; A61B10/00; A61K39/395; A61P9/12; A61P11/00; G01N33/53
Domestic Patent References:
| WO2014192915A1 | 2014-12-04 | |||
| WO2017122666A1 | 2017-07-20 |
Other References:
"Guidelines for Treatment of Pulmonary Hypertension (JCS 2017/JPCPHS 2017)", 2018, pages 11 - 19
CHIAKI IWAMURA IWAMURA: "Elevated Myl9 reflects the Myl9-containing microthrombi in SARS-CoV-2-induced lung exudative vasculitis and predicts COVID-19 severity", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 119, no. 33, 27 July 2022 (2022-07-27), pages 1 - 11, XP093160308, ISSN: 0027-8424
KOJI HAYASHIZAKI, KIMURA MOTOKO Y., TOKOYODA KOJI, HOSOKAWA HIROYUKI, SHINODA KENTA, HIRAHARA KIYOSHI, ICHIKAWA TOMOMI, ONODERA AT: "Myosin light chains 9 and 12 are functional ligands for CD69 that regulate airway inflammation", SCIENCE IMMUNOLOGY, AAAS, US, vol. 1, no. 3, 16 September 2016 (2016-09-16), US , pages eaaf9154 - eaaf9154, XP055335879, ISSN: 2470-9468, DOI: 10.1126/sciimmunol.aaf9154
AIKO OGAWA, HIROMI MATSUBARA: "S5-3 The roles of thrombogenesis in the progression of PH", PROGRAMS AND ABSTRACTS OF JOINT ACADEMIC MEETING OF 4TH JAPANESE PULMONARY CIRCULATION SOCIETY AND 3RD JAPANESE PULMONARY HYPERTENSION SOCIETY; OCTOBER 3-4, 2015, JAPANESE PULMONARY CIRCULATION SOCIETY, JAPANESE PULMONARY HYPERTENSION SOCIETY, JP, 4 October 2015 (2015-10-04) - 4 October 2015 (2015-10-04), JP, pages 72 - 72, XP009554215
NOBUHIRO TAHARA: "S5-1: Disease activity of PH evaluated by molecular imaging", PROGRAMS AND ABSTRACTS OF JOINT ACADEMIC MEETING OF 4TH JAPANESE PULMONARY CIRCULATION SOCIETY AND 3RD JAPANESE PULMONARY HYPERTENSION SOCIETY; OCTOBER 3-4, 2015, JAPANESE PULMONARY CIRCULATION SOCIETY, JAPANESE PULMONARY HYPERTENSION SOCIETY, JP, 1 January 2015 (2015-01-01) - 4 October 2015 (2015-10-04), JP, pages 71 - 71, XP009554214
CHIAKI IWAMURA IWAMURA: "Elevated Myl9 reflects the Myl9-containing microthrombi in SARS-CoV-2-induced lung exudative vasculitis and predicts COVID-19 severity", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 119, no. 33, 27 July 2022 (2022-07-27), pages 1 - 11, XP093160308, ISSN: 0027-8424
KOJI HAYASHIZAKI, KIMURA MOTOKO Y., TOKOYODA KOJI, HOSOKAWA HIROYUKI, SHINODA KENTA, HIRAHARA KIYOSHI, ICHIKAWA TOMOMI, ONODERA AT: "Myosin light chains 9 and 12 are functional ligands for CD69 that regulate airway inflammation", SCIENCE IMMUNOLOGY, AAAS, US, vol. 1, no. 3, 16 September 2016 (2016-09-16), US , pages eaaf9154 - eaaf9154, XP055335879, ISSN: 2470-9468, DOI: 10.1126/sciimmunol.aaf9154
AIKO OGAWA, HIROMI MATSUBARA: "S5-3 The roles of thrombogenesis in the progression of PH", PROGRAMS AND ABSTRACTS OF JOINT ACADEMIC MEETING OF 4TH JAPANESE PULMONARY CIRCULATION SOCIETY AND 3RD JAPANESE PULMONARY HYPERTENSION SOCIETY; OCTOBER 3-4, 2015, JAPANESE PULMONARY CIRCULATION SOCIETY, JAPANESE PULMONARY HYPERTENSION SOCIETY, JP, 4 October 2015 (2015-10-04) - 4 October 2015 (2015-10-04), JP, pages 72 - 72, XP009554215
NOBUHIRO TAHARA: "S5-1: Disease activity of PH evaluated by molecular imaging", PROGRAMS AND ABSTRACTS OF JOINT ACADEMIC MEETING OF 4TH JAPANESE PULMONARY CIRCULATION SOCIETY AND 3RD JAPANESE PULMONARY HYPERTENSION SOCIETY; OCTOBER 3-4, 2015, JAPANESE PULMONARY CIRCULATION SOCIETY, JAPANESE PULMONARY HYPERTENSION SOCIETY, JP, 1 January 2015 (2015-01-01) - 4 October 2015 (2015-10-04), JP, pages 71 - 71, XP009554214
Attorney, Agent or Firm:
OHTANI PATENT OFFICE (JP)
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