METHOD FOR CONSTRUCTING GRAM-NEGATIVE BACTERIAL OUTER MEMBRANE-DERIVED NANOVESICLES AND USE THEREOF

WIPO Patent Application WO/2023/229446

A1

The present invention relates to a method for constructing Gram-negative bacterial outer membrane-derived nanovesicles and a use thereof. Also, the present invention provides a method for treating or diagnosing cancer using Gram-negative bacterial outer membrane-derived nanovesicles. In addition, the present invention provides a method for delivering therapeutic or diagnostic materials to target cells or tissues by loading same into Gram-negative bacterial outer membrane-derived nanovesicles. Furthermore, the present invention provides a method for the prevention and treatment of various diseases including cancer and bacterial/viral infections by co-administering Gram-negative bacterial outer membrane-derived nanovesicles and antigens or by administering Gram-negative bacterial outer membrane-derived nanovesicles having antigens expressed thereon.

GHO YONG SONG (KR)
LEE JIE OH (KR)
LEE CHANG JIN (KR)
ROH TAE YOUNG (KR)
LEE TAE RYONG (KR)
BAE SEO YOON (KR)
SHIN HA YOUNG (KR)
JEONG HYE JIN (KR)
YOO MI JOUNG (KR)
SONG SUNG HYUN (KR)
LEE JAE WOOK (KR)

PCT/KR2023/007333

November 30, 2023

May 26, 2023

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ROSETTA EXOSOME CO LTD (KR)
POSTECH RES & BUSINESS DEV FOUND (KR)

C12N1/20; A61K39/00; A61K47/46; C12N15/88

KR102212335B1	2021-02-04
KR20120084900A	2012-07-31
US20150202274A1	2015-07-23
US20140004178A1	2014-01-02

KYONG-SU PARK, KYOUNG-HO CHOI, YOU-SUN KIM, BOK SIL HONG, OH YOUN KIM, JI HYUN KIM, CHANG MIN YOON, GOU-YOUNG KOH, YOON-KEUN KIM, : "Outer Membrane Vesicles Derived from Escherichia coli Induce Systemic Inflammatory Response Syndrome", PLOS ONE, vol. 5, no. 6, 28 June 2010 (2010-06-28), pages e11334, XP055096408, DOI: 10.1371/journal.pone.0011334

LEE, Hee Sook (KR)

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