Title:
M PROTEIN DETECTION METHOD
Document Type and Number:
WIPO Patent Application WO/2024/082581
Kind Code:
A1
Abstract:
The present invention relates to the field of biomedicine, and in particular, to an M protein detection method. The method comprises: 1) providing m/z distribution data of singly-charged ions in immunoglobulin light chains in samples to be detected, the light chains comprising a λ light chain and a κ light chain; and 2) performing result determination: if there is, in the m/z range of the light chains, a mass spectrum peak which has a narrow base and is high and sharp, determining that said samples contain M proteins, or if the peak area ratio of the κ light chain to the λ light chain is less than 1.8 or greater than 3.5, and the peak shape is in a non-Gaussian distribution, determining that said samples contains M proteins.
Inventors:
ZHOU HONGWEI (CN)
ZENG NIANYI (CN)
HUANG JUNDA (CN)
FANG ZHENCHENG (CN)
CHEN MUXUAN (CN)
ZENG NIANYI (CN)
HUANG JUNDA (CN)
FANG ZHENCHENG (CN)
CHEN MUXUAN (CN)
Application Number:
PCT/CN2023/087606
Publication Date:
April 25, 2024
Filing Date:
April 11, 2023
Export Citation:
Assignee:
ZHUJIANG HOSPITAL SOUTHERN MEDICAL UNIV (CN)
International Classes:
G01N33/68; G01N27/62; G01N33/574; G06F18/214; G06F18/2431; G16B40/20
Foreign References:
| CN115684606A | 2023-02-03 | |||
| CN113720900A | 2021-11-30 | |||
| CN104272113A | 2015-01-07 | |||
| CN104598767A | 2015-05-06 | |||
| CN109753939A | 2019-05-14 | |||
| CN113811772A | 2021-12-17 | |||
| US20160041184A1 | 2016-02-11 | |||
| US20210247402A1 | 2021-08-12 | |||
| US20220221469A1 | 2022-07-14 |
Attorney, Agent or Firm:
J.Z.M.C. PATENT AND TRADEMARK LAW OFFICE (GENERAL PARTNERSHIP) (CN)
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