Title:
LABELING METHOD, OXIDANT FOR LABELING, RUTHENIUM COMPLEX, CATALYST, LABELING COMPOUND, AND COMPOUND
Document Type and Number:
WIPO Patent Application WO/2022/138748
Kind Code:
A1
Abstract:
The present invention provides a labeling method that comprises a step for labeling a substrate, which has a carbon-hydrogen bond, with an oxygen isotope with use of a catalyst and an oxidant that is produced from a hypervalent iodine compound having an ester structure and labeled water which is labeled with at least one oxygen isotope that is selected from the group consisting of 17O and 18O. The present invention also provides an oxidant for labeling, said oxidant being produced from a hypervalent iodine compound having an ester structure and labeled water which is labeled with at least one oxygen isotope that is selected from the group consisting of 17O and 18O. This oxidant for labeling labels a substrate, which has a carbon-hydrogen bond, with an oxygen isotope in the coexistence of a catalyst.
Inventors:
UCHIDA TATSUYA (JP)
DOIUCHI DAIKI (JP)
NAKAMURA TATSUYA (JP)
SHIMODA NANAKO (JP)
DOIUCHI DAIKI (JP)
NAKAMURA TATSUYA (JP)
SHIMODA NANAKO (JP)
Application Number:
PCT/JP2021/047658
Publication Date:
June 30, 2022
Filing Date:
December 22, 2021
Export Citation:
Assignee:
UNIV KYUSHU NAT UNIV CORP (JP)
International Classes:
C07B59/00; A61K51/04; B01J31/24; C07B61/00; C07C29/48; C07C35/37; C07C67/29; C07C69/16; C07C69/78; C07C71/00; C07F15/00; C07H1/00; C07H3/02; C07H3/10
Foreign References:
| JP2006008591A | 2006-01-12 | |||
| JP2006008666A | 2006-01-12 | |||
| JP2020037545A | 2020-03-12 |
Other References:
DOIUCHI DAIKI, UCHIDA TATSUYA: "Catalytic Highly Regioselective C–H Oxygenation Using Water as the Oxygen Source: Preparation of 17 O/ 18 O-Isotope-Labeled Compounds", ORGANIC LETTERS, AMERICAN CHEMICAL SOCIETY, US, vol. 23, no. 18, 17 September 2021 (2021-09-17), US , pages 7301 - 7305, XP055945242, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.1c02812
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
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