Title:
KERATIN YK93-2, AND PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/074107
Kind Code:
A1
Abstract:
The present invention belongs to the field of biopharmaceuticals. Provided are a keratin YK93-2, a nucleic acid molecule encoding the same, an expression vector comprising the nucleic acid molecule, a host cell comprising the expression vector or with the genome integrated with the nucleic acid molecule, a preparation method therefor and a pharmaceutical composition thereof. Further provided is the use of the above-mentioned product, such as keratin YK93-2 in the preparation of a drug for treating lung cancer, lymphoma, breast cancer, melanoma, uterine fibroid, prostatic hyperplasia, etc.
Inventors:
YU SHISHAN (CN)
CHEN XIAOGUANG (CN)
LIU YUNBAO (CN)
JIN JING (CN)
LI MI (CN)
QU JING (CN)
LI YONG (CN)
HAO MENGYAO (CN)
WANG XIAOJING (CN)
WANG MINGJIN (CN)
SHI GUORU (CN)
JIANG HUIMIN (CN)
MA SHUANGGANG (CN)
FU JIANG (CN)
LI SHUYING (CN)
CHEN XIAOGUANG (CN)
LIU YUNBAO (CN)
JIN JING (CN)
LI MI (CN)
QU JING (CN)
LI YONG (CN)
HAO MENGYAO (CN)
WANG XIAOJING (CN)
WANG MINGJIN (CN)
SHI GUORU (CN)
JIANG HUIMIN (CN)
MA SHUANGGANG (CN)
FU JIANG (CN)
LI SHUYING (CN)
Application Number:
PCT/CN2023/121633
Publication Date:
April 11, 2024
Filing Date:
September 26, 2023
Export Citation:
Assignee:
INST MATERIA MEDICA CAMS (CN)
International Classes:
C07K14/47; A61K38/17; A61P13/08; A61P15/14; A61P29/00; A61P35/00; C12N1/21; C12N15/12; C12N15/70; C12P21/02
Foreign References:
| CN112724233A | 2021-04-30 | |||
| CN112022866A | 2020-12-04 | |||
| CN107428821A | 2017-12-01 | |||
| CN116535486A | 2023-08-04 |
Other References:
DATABASE Protein 28 October 2020 (2020-10-28), ANONYMOUS: "keratin, type II cuticular Hb1 [Manis pentadactyla]", XP093154856, retrieved from NCBI Database accession no. XP_036771049.1
KUN ZHANG: "KRT81 Knockdown Inhibits Malignant Progression of Melanoma Through Regulating Interleukin-8", DNA AND CELL BIOLOGY, MARY ANN LIEBERT, NEW YORK, NY, US, vol. 40, no. 10, 1 October 2021 (2021-10-01), US , pages 1290 - 1297, XP093154861, ISSN: 1044-5498, DOI: 10.1089/dna.2021.0317
GUIMIN ZHAO: "Association of rs3660 Single Nucleotide Polymorphisms with Non-Hodgkin's Lymphoma ", JOURNAL OF CHINA MEDICAL UNIVERSITY, vol. 46, no. 4, 12 April 2017 (2017-04-12), pages 321 - 325, XP093154863, DOI: 10.12007/j.issn.0258•4646.2017.04.009
KUN ZHANG: "KRT81 Knockdown Inhibits Malignant Progression of Melanoma Through Regulating Interleukin-8", DNA AND CELL BIOLOGY, MARY ANN LIEBERT, NEW YORK, NY, US, vol. 40, no. 10, 1 October 2021 (2021-10-01), US , pages 1290 - 1297, XP093154861, ISSN: 1044-5498, DOI: 10.1089/dna.2021.0317
GUIMIN ZHAO: "Association of rs3660 Single Nucleotide Polymorphisms with Non-Hodgkin's Lymphoma ", JOURNAL OF CHINA MEDICAL UNIVERSITY, vol. 46, no. 4, 12 April 2017 (2017-04-12), pages 321 - 325, XP093154863, DOI: 10.12007/j.issn.0258•4646.2017.04.009
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
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