Title:
ION CROSS-LINKED BIOMIMETIC MEMBRANE, PREPARATION METHOD THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/055284
Kind Code:
A1
Abstract:
The present invention provides an ion cross-linked biomimetic membrane. The biomimetic membrane is formed by self-assembly of an amphiphilic block copolymer. Hydrophilic chains of the amphiphilic block copolymer are cross-linked by means of a cross-linking agent. The hydrophilic chain segments of the amphiphilic block copolymer have opposite charges to the cross-linking agent in an aqueous solution. Compared with the prior art, the present invention utilizes the cross-linking agent having a charge opposite to the charge of the amphiphilic block copolymer to generate a bridging effect by means of electrostatic adsorption to form, in the form of ionic bonds, cross-links from adjacent hydrophilic chain segments, such that intermolecular gaps of an amphiphilic molecular membrane formed by self-assembly of the amphiphilic block copolymer decreases, the stability of the membrane is enhanced, and the electrical resistance and the mechanical strength of the membrane are increased, such that the membrane has a lower leakage current and a longer service life when used for biosensing.
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Inventors:
WANG SHENGWEN (CN)
WANG ZHAOHUI (CN)
YUN QUANXIN (CN)
ZENG TAO (CN)
DONG YULIANG (CN)
LI YUXIANG (CN)
ZHANG WENWEI (CN)
TENG BO (CN)
XU XUN (CN)
WANG ZHAOHUI (CN)
YUN QUANXIN (CN)
ZENG TAO (CN)
DONG YULIANG (CN)
LI YUXIANG (CN)
ZHANG WENWEI (CN)
TENG BO (CN)
XU XUN (CN)
Application Number:
PCT/CN2022/119287
Publication Date:
March 21, 2024
Filing Date:
September 16, 2022
Export Citation:
Assignee:
BGI SHENZHEN (CN)
International Classes:
B01D69/02; B01D69/12; B01D71/80; C08G77/452; C08G81/00
Domestic Patent References:
| WO2012161662A1 | 2012-11-29 |
Foreign References:
| US20020037986A1 | 2002-03-28 | |||
| CN106459410A | 2017-02-22 | |||
| CN110690486A | 2020-01-14 | |||
| CN110052172A | 2019-07-26 | |||
| CN113856486A | 2021-12-31 | |||
| CN105188905A | 2015-12-23 | |||
| CN104936682A | 2015-09-23 |
Attorney, Agent or Firm:
UNITALEN ATTORNEYS AT LAW CO., LTD. (CN)
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