Title:
HIGH-THROUGHPUT NUCLEIC ACID SYNTHESIS CHIP AND USE METHOD THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/116712
Kind Code:
A1
Abstract:
A chip for nucleic acid synthesis. The chip comprises a plurality of synthesis units; each synthesis unit comprises a plurality of three-dimensional layers; the first layer of the plurality of three-dimensional layers is a synthesis layer of a short nucleic acid sequence, and the second layer to the last layer are splicing layers of a nucleic acid sequence, wherein a plurality of synthesis reaction points exist in the first layer to synthesize a plurality of short nucleic acid sequences, and splicing reaction points exist on the second layer to the last layer so as to orderly splice the shorter nucleic acid sequences synthesized on the previous layer into longer nucleic acid sequences until a nucleic acid sequence having a complete length is generated.
Inventors:
CHEN HAO (CN)
ZHANG BAOLIANG (CN)
ZHI YAN (CN)
QIAN ZICHEN (CN)
ZHANG BAOLIANG (CN)
ZHI YAN (CN)
QIAN ZICHEN (CN)
Application Number:
PCT/CN2022/140424
Publication Date:
June 29, 2023
Filing Date:
December 20, 2022
Export Citation:
Assignee:
INNOVEL INTELLIGENT TECH CO LTD (CN)
WUXI BIOLOGICS SHANGHAI CO LTD (CN)
WUXI BIOLOGICS IRELAND LTD (IE)
WUXI BIOLOGICS SHANGHAI CO LTD (CN)
WUXI BIOLOGICS IRELAND LTD (IE)
International Classes:
C12N15/10; B01J14/00; C12M1/00; C12P19/34
Domestic Patent References:
| WO2021137844A1 | 2021-07-08 |
Foreign References:
| CN111246936A | 2020-06-05 | |||
| CN106536734A | 2017-03-22 | |||
| CN103945931A | 2014-07-23 | |||
| JP2005272371A | 2005-10-06 | |||
| CN110468171A | 2019-11-19 | |||
| CN105238777A | 2016-01-13 |
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
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