Title:
HIGH THROUGHPUT METHOD FOR CONSTRUCTING AND SCREENING COMPOUND LIBRARY AND REACTION DEVICE
Document Type and Number:
WIPO Patent Application WO/2021/004326
Kind Code:
A1
Abstract:
The present invention provides a high throughput method for constructing and screening a compound library and a reaction device. Specifically, the method of the present invention comprises: (a) providing a reactor comprising n independent and addressable reaction chambers; (b) performing m independent synthesis reactions in said n reaction chambers, thereby constructing a compound library; and (c) performing activity tests in reaction chambers in which synthesis reactions are performed. In the present invention, the preparation and screening processes of a compound can be completed in the same reaction system. As the reactions of the present invention almost quantitatively generate products, the products can be directly used in enzymatic or even cytological activity test experiments without separation.
Inventors:
DONG JIAJIA (CN)
SHARPLESS KARL BARRY (CN)
MENG GENYI (CN)
GUO TAIJIE (CN)
MA TIANCHENG (CN)
SHARPLESS KARL BARRY (CN)
MENG GENYI (CN)
GUO TAIJIE (CN)
MA TIANCHENG (CN)
Application Number:
PCT/CN2020/099034
Publication Date:
January 14, 2021
Filing Date:
June 29, 2020
Export Citation:
Assignee:
SHANGHAI INST ORGANIC CHEMISTRY CAS (CN)
International Classes:
C40B50/00; C40B60/02
Domestic Patent References:
| WO2009105746A2 | 2009-08-27 | |||
| WO2009105746A2 | 2009-08-27 |
Foreign References:
| US20060172881A1 | 2006-08-03 |
Other References:
CAREYSUNDBERG: "ADVANCED ORGANIC CHEMISTRY", 2000, PLENUM PRESS
See also references of EP 3995611A4
See also references of EP 3995611A4
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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