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Title:
HIGH-AFFINITY PD1 PROTEIN CONJUGATE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/066616
Kind Code:
A1
Abstract:
Provided is a high-affinity PD1 protein conjugate, which comprises an elastin-like polypeptide and a high-affinity PD1 protein connected to the elastin-like polypeptide. The conjugate significantly improves the biological half-life and bioavailability of the high-affinity PD1 protein and has tumor targeting and permeability and tumor microenvironment temperature responsiveness.

Inventors:
GAO WEIPING (CN)
GAO CHUNHONG (CN)
Application Number:
PCT/CN2023/104977
Publication Date:
April 04, 2024
Filing Date:
June 30, 2023
Export Citation:
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Assignee:
UNIV BEIJING (CN)
International Classes:
C07K19/00; A61K38/16; A61P35/00; C12N5/10; C12N15/62; C12N15/63
Domestic Patent References:
WO2022187488A22022-09-09
Foreign References:
CN107108707A2017-08-29
CN110101868A2019-08-09
CN101500606A2009-08-05
CN103230598A2013-08-07
Attorney, Agent or Firm:
CN-KNOWHOW INTELLECTUAL PROPERTY AGENT LIMITED (CN)
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