Title:
GSPT1 DEGRADERS, COMPOSITIONS COMPRISING THE DEGRADER, AND METHODS OF USING THE SAME
Document Type and Number:
WIPO Patent Application WO/2024/073871
Kind Code:
A1
Abstract:
It provides compounds of Formula I, a tautomer thereof, a deuterated derivative of the compound or the tautomer, and a pharmaceutically acceptable salt of the foregoing. It also provides compositions comprising the compounds of Formula I, a tautomer thereof, a deuterated derivative of the compound or the tautomer, and/or a pharmaceutically acceptable salt of the foregoing, and methods of using the same, in treating, for example, the diseases, disorders, or conditions mediated by the degradation of G1 to S phase transition protein 1 (GSPT1).
Inventors:
FANG LICHAO (CN)
LIU MIAO (CN)
MA TIANWEI (CN)
LIU MIAO (CN)
MA TIANWEI (CN)
Application Number:
PCT/CN2022/123708
Publication Date:
April 11, 2024
Filing Date:
October 04, 2022
Export Citation:
Assignee:
BIOFRONT LTD (KY)
FANG LICHAO (CN)
FANG LICHAO (CN)
International Classes:
C07D401/14; A61K31/403; A61K31/44; A61P35/00; A61P35/02; C07D403/14
Domestic Patent References:
| WO2021126974A1 | 2021-06-24 | |||
| WO2021126973A1 | 2021-06-24 | |||
| WO2022066835A1 | 2022-03-31 | |||
| WO2021053555A1 | 2021-03-25 | |||
| WO2021087093A1 | 2021-05-06 |
Other References:
JOSHUA D. HANSEN, KEVIN CONDROSKI, MATTHEW CORREA, GEORGE MULLER, HON-WAH MAN, ALEXANDER RUCHELMAN, WEIHONG ZHANG, FAN VOCANSON, T: "Protein Degradation via CRL4 CRBN Ubiquitin Ligase: Discovery and Structure–Activity Relationships of Novel Glutarimide Analogs That Promote Degradation of Aiolos and/or GSPT1", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 61, no. 2, 25 January 2018 (2018-01-25), US , pages 492 - 503, XP055757970, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.6b01911
Attorney, Agent or Firm:
WU, FENG & ZHANG (CN)
Download PDF:
Previous Patent: PATH TRAJECTORY FUNCTIONAL ENCRYPTION
Next Patent: PROVIDE ACTION SUGGESTION FOR A COMMUNICATION SESSION
Next Patent: PROVIDE ACTION SUGGESTION FOR A COMMUNICATION SESSION