Title:
GENETICALLY MODIFIED ANIMAL-DERIVED ANIMAL FIBER
Document Type and Number:
WIPO Patent Application WO/2023/234412
Kind Code:
A1
Abstract:
The present invention provides: a non-human animal having a novel fiber; and a method for producing the non-human animal. Specifically, the present invention provides: a non-human animal with reduced expression or functions of at least one gene constituting a Krt or KAP family; and a method for producing the non-human animal.
Inventors:
SAWATSUBASHI SHUN (JP)
INATANI YUKA (JP)
WATANABE TADAYOSHI (JP)
NAGAO YUSUKE (JP)
AGARI TAKAHIRO (JP)
KAINUMA RISA (JP)
NAGAO TOMOKO (JP)
NISHIMURA KOICHI (JP)
HOZUMI SHUNYA (JP)
ONO AKIHIRO (JP)
INATANI YUKA (JP)
WATANABE TADAYOSHI (JP)
NAGAO YUSUKE (JP)
AGARI TAKAHIRO (JP)
KAINUMA RISA (JP)
NAGAO TOMOKO (JP)
NISHIMURA KOICHI (JP)
HOZUMI SHUNYA (JP)
ONO AKIHIRO (JP)
Application Number:
PCT/JP2023/020690
Publication Date:
December 07, 2023
Filing Date:
June 02, 2023
Export Citation:
Assignee:
SETSUROTECH INC (JP)
OPTAGE INC (JP)
OPTAGE INC (JP)
International Classes:
A01K67/027; D02G3/02; D03D15/233; D04B1/14; D04B21/00; C12N15/09; C12N15/12
Other References:
JACINTO JOANA G. P., MARKEY ALYSTA D., VEIGA INÊS M. B., PARIS JULIA M., WELLE MONIKA, BEEVER JONATHAN E., DRÖGEMÜLLER CORD: "A KRT71 Loss-of-Function Variant Results in Inner Root Sheath Dysplasia and Recessive Congenital Hypotrichosis of Hereford Cattle", GENES, MDPI AG, US, vol. 12, no. 7, US , pages 1038, XP093115321, ISSN: 2073-4425, DOI: 10.3390/genes12071038
E. SALMELA; J. NISKANEN; M. ARUMILLI; J. DONNER; H. LOHI; M. K. HYTÖNEN: "A novel KRT71 variant in curly‐coated dogs", ANIMAL GENETICS., BLACKWELL SCIENTIFIC PUBLICATIONS, LONDON., GB, vol. 50, no. 1, 19 November 2018 (2018-11-19), GB , pages 101 - 104, XP071536882, ISSN: 0268-9146, DOI: 10.1111/age.12746
SHU WEI LI; HONG SHENG OUYANG; GEORGE ERNEST ROGERS; CHRISTOPHER SIMON BAWDEN: "Characterization of the structural and molecular defects in fibres and follicles of the merino felting lustre mutant", EXPERIMENTAL DERMATOLOGY, BLACKWELL MUNSGAARD, COPENHAGEN; DK, vol. 18, no. 2, 10 July 2008 (2008-07-10), COPENHAGEN; DK , pages 134 - 142, XP071776594, ISSN: 0906-6705, DOI: 10.1111/j.1600-0625.2008.00774.x
DATABASE MGI August 2017 (2017-08-01), ANONYMOUS : "keratin 26; endonuclease-mediated mutation 1, Korea Mouse Phenotyping Center", XP093115330, Database accession no. 6156299
REICHELT JULIA, MAGIN THOMAS M.: "Hyperproliferation, induction of c-Myc and 14-3-3σ, but no cell fragility in keratin-10-null mice", JOURNAL OF CELL SCIENCE, COMPANY OF BIOLOGISTS LIMITED, CAMBRIDGE, vol. 115, no. 13, 1 July 2002 (2002-07-01), Cambridge , pages 2639 - 2650, XP093115331, ISSN: 0021-9533, DOI: 10.1242/jcs.115.13.2639
LLOYDS C, ET AL.: "THE BASAL KERATIN NETWORK OF STRATIFIED SQUAMOUS EPITHELIA: DEFINING K15 FUNCTION IN THE ABSENCE OF K14", THE JOURNAL OF CELL BIOLOGY, THE ROCKEFELLER UNIVERSITY PRESS, US, vol. 129, no. 5, 1 June 1995 (1995-06-01), US , pages 1329 - 1344, XP002500576, ISSN: 0021-9525, DOI: 10.1083/jcb.129.5.1329
MCGOWAN KEVIN M., TONG XUEMEI, COLUCCI-GUYON EMMA, LANGA FRANCINA, BABINET CHARLES, COULOMBE PIERRE A.: "Keratin 17 null mice exhibit age- and strain-dependent alopecia", GENES & DEVELOPMENT, COLD SPRING HARBOR LABORATORY PRESS, PLAINVIEW, NY., US, vol. 16, no. 11, 1 June 2002 (2002-06-01), US , pages 1412 - 1422, XP093115332, ISSN: 0890-9369, DOI: 10.1101/gad.979502
MINH HO;BRIAN THOMPSON;JEFFREYNICHOLAS FISK;DANIELW. NEBERT;ELSPETHA. BRUFORD;VASILIS VASILIOU;CHRISTOPHERG. BUNICK: "Update of the keratin gene family: evolution, tissue-specific expression patterns, and relevance to clinical disorders", HUMAN GENOMICS, BIOMED CENTRAL LTD, LONDON, UK, vol. 16, no. 1, 6 January 2022 (2022-01-06), London, UK, pages 1 - 21, XP021301042, DOI: 10.1186/s40246-021-00374-9
GONG HUA, ZHOU HUITONG, FORREST RACHEL, LI SHAOBIN, WANG JIQING, DYER JOLON, LUO YUZHU, HICKFORD JON: "Wool Keratin-Associated Protein Genes in Sheep—A Review", GENES, MDPI AG, US, vol. 7, no. 6, US , pages 24, XP093115333, ISSN: 2073-4425, DOI: 10.3390/genes7060024
WANG XIAOLONG, CAI BEI, ZHOU JIANKUI, ZHU HAIJING, NIU YIYUAN, MA BAOHUA, YU HONGHAO, LEI ANMIN, YAN HAILONG, SHEN QIAOYAN, SHI LE: "Disruption of FGF5 in Cashmere Goats Using CRISPR/Cas9 Results in More Secondary Hair Follicles and Longer Fibers", PLOS ONE, PUBLIC LIBRARY OF SCIENCE, US, vol. 11, no. 10, 18 October 2016 (2016-10-18), US , pages e0164640, XP093115341, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0164640
BEERMANN FRIEDRICH, ORLOW SETH J., LAMOREUX M. LYNN: "The Tyr (albino) locus of the laboratory mouse", MAMMALIAN GENOME, SPRINGER NEW YORK LLC, US, vol. 15, no. 10, 1 October 2004 (2004-10-01), US , pages 749 - 758, XP093115342, ISSN: 0938-8990, DOI: 10.1007/s00335-004-4002-8
E. SALMELA; J. NISKANEN; M. ARUMILLI; J. DONNER; H. LOHI; M. K. HYTÖNEN: "A novel KRT71 variant in curly‐coated dogs", ANIMAL GENETICS., BLACKWELL SCIENTIFIC PUBLICATIONS, LONDON., GB, vol. 50, no. 1, 19 November 2018 (2018-11-19), GB , pages 101 - 104, XP071536882, ISSN: 0268-9146, DOI: 10.1111/age.12746
SHU WEI LI; HONG SHENG OUYANG; GEORGE ERNEST ROGERS; CHRISTOPHER SIMON BAWDEN: "Characterization of the structural and molecular defects in fibres and follicles of the merino felting lustre mutant", EXPERIMENTAL DERMATOLOGY, BLACKWELL MUNSGAARD, COPENHAGEN; DK, vol. 18, no. 2, 10 July 2008 (2008-07-10), COPENHAGEN; DK , pages 134 - 142, XP071776594, ISSN: 0906-6705, DOI: 10.1111/j.1600-0625.2008.00774.x
DATABASE MGI August 2017 (2017-08-01), ANONYMOUS : "keratin 26; endonuclease-mediated mutation 1, Korea Mouse Phenotyping Center", XP093115330, Database accession no. 6156299
REICHELT JULIA, MAGIN THOMAS M.: "Hyperproliferation, induction of c-Myc and 14-3-3σ, but no cell fragility in keratin-10-null mice", JOURNAL OF CELL SCIENCE, COMPANY OF BIOLOGISTS LIMITED, CAMBRIDGE, vol. 115, no. 13, 1 July 2002 (2002-07-01), Cambridge , pages 2639 - 2650, XP093115331, ISSN: 0021-9533, DOI: 10.1242/jcs.115.13.2639
LLOYDS C, ET AL.: "THE BASAL KERATIN NETWORK OF STRATIFIED SQUAMOUS EPITHELIA: DEFINING K15 FUNCTION IN THE ABSENCE OF K14", THE JOURNAL OF CELL BIOLOGY, THE ROCKEFELLER UNIVERSITY PRESS, US, vol. 129, no. 5, 1 June 1995 (1995-06-01), US , pages 1329 - 1344, XP002500576, ISSN: 0021-9525, DOI: 10.1083/jcb.129.5.1329
MCGOWAN KEVIN M., TONG XUEMEI, COLUCCI-GUYON EMMA, LANGA FRANCINA, BABINET CHARLES, COULOMBE PIERRE A.: "Keratin 17 null mice exhibit age- and strain-dependent alopecia", GENES & DEVELOPMENT, COLD SPRING HARBOR LABORATORY PRESS, PLAINVIEW, NY., US, vol. 16, no. 11, 1 June 2002 (2002-06-01), US , pages 1412 - 1422, XP093115332, ISSN: 0890-9369, DOI: 10.1101/gad.979502
MINH HO;BRIAN THOMPSON;JEFFREYNICHOLAS FISK;DANIELW. NEBERT;ELSPETHA. BRUFORD;VASILIS VASILIOU;CHRISTOPHERG. BUNICK: "Update of the keratin gene family: evolution, tissue-specific expression patterns, and relevance to clinical disorders", HUMAN GENOMICS, BIOMED CENTRAL LTD, LONDON, UK, vol. 16, no. 1, 6 January 2022 (2022-01-06), London, UK, pages 1 - 21, XP021301042, DOI: 10.1186/s40246-021-00374-9
GONG HUA, ZHOU HUITONG, FORREST RACHEL, LI SHAOBIN, WANG JIQING, DYER JOLON, LUO YUZHU, HICKFORD JON: "Wool Keratin-Associated Protein Genes in Sheep—A Review", GENES, MDPI AG, US, vol. 7, no. 6, US , pages 24, XP093115333, ISSN: 2073-4425, DOI: 10.3390/genes7060024
WANG XIAOLONG, CAI BEI, ZHOU JIANKUI, ZHU HAIJING, NIU YIYUAN, MA BAOHUA, YU HONGHAO, LEI ANMIN, YAN HAILONG, SHEN QIAOYAN, SHI LE: "Disruption of FGF5 in Cashmere Goats Using CRISPR/Cas9 Results in More Secondary Hair Follicles and Longer Fibers", PLOS ONE, PUBLIC LIBRARY OF SCIENCE, US, vol. 11, no. 10, 18 October 2016 (2016-10-18), US , pages e0164640, XP093115341, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0164640
BEERMANN FRIEDRICH, ORLOW SETH J., LAMOREUX M. LYNN: "The Tyr (albino) locus of the laboratory mouse", MAMMALIAN GENOME, SPRINGER NEW YORK LLC, US, vol. 15, no. 10, 1 October 2004 (2004-10-01), US , pages 749 - 758, XP093115342, ISSN: 0938-8990, DOI: 10.1007/s00335-004-4002-8
Attorney, Agent or Firm:
MORITA Yutaka (JP)
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