Title:
GENE THERAPY OF HIPPO SIGNALING IMPROVES HEART FUNCTION IN A CLINICALLY RELEVANT MODEL
Document Type and Number:
WIPO Patent Application WO/2024/006898
Kind Code:
A3
Abstract:
Embodiments of the disclosure include methods and compositions for improving heart function, including reducing the risk of arrhythmia in an individual in need thereof. In particular embodiments, an individual with a need for improved heart function and/or reduced risk of arrhythmia is provided an effective amount of a shRNA molecule that targets the Sav1 gene.
Inventors:
MARTIN JAMES F (US)
LEACH JOHN P (US)
LIU SHIJIE (US)
ZHANG SUI (US)
LEACH JOHN P (US)
LIU SHIJIE (US)
ZHANG SUI (US)
Application Number:
PCT/US2023/069359
Publication Date:
April 11, 2024
Filing Date:
June 29, 2023
Export Citation:
Assignee:
BAYLOR COLLEGE MEDICINE (US)
TEXAS HEART INST (US)
YAP THERAPEUTICS INC (US)
TEXAS HEART INST (US)
YAP THERAPEUTICS INC (US)
International Classes:
C12N15/113; A61K31/7088; A61P9/04; A61P9/10; A61K31/713; A61P9/00; C07H21/02
Foreign References:
| US20160312219A1 | 2016-10-27 | |||
| US20200206327A1 | 2020-07-02 |
Other References:
SHIJIE LIU: "Gene therapy knockdown of Hippo signaling induces cardiomyocyte renewal in pigs after myocardial infarction", SCIENCE TRANSLATIONAL MEDICINE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, vol. 13, no. 600, 30 June 2021 (2021-06-30), XP093159840, ISSN: 1946-6234, DOI: 10.1126/scitranslmed.abd6892
Attorney, Agent or Firm:
EDDY, Sarah D. (US)
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