Title:
FINE PARTICLES, NK CELL ACTIVATOR, CULTURE METHOD FOR NK CELLS, PRODUCTION METHOD FOR ACTIVATED NK CELLS, AND ACTIVATION METHOD FOR NK CELLS
Document Type and Number:
WIPO Patent Application WO/2024/070382
Kind Code:
A1
Abstract:
The present invention provides: novel fine particles that include miRNA associated with NK cell activation and that are derived from a culture supernatant of stem cells derived from dental pulp or a culture supernatant of stem cells derived from fat, the fine particles being capable of controlling the expression of a protein and/or a gene associated with NK cell activation; an NK cell activator; a culture method for NK cells; a production method for activated NK cells; NK cells; and an activation method for NK cells.
Inventors:
KOGA SHOJI (JP)
Application Number:
PCT/JP2023/030834
Publication Date:
April 04, 2024
Filing Date:
August 27, 2023
Export Citation:
Assignee:
PANAGY CO LTD (JP)
International Classes:
C12N5/0797; A61K35/28; A61K35/30; A61P37/04; A61P43/00; C12N5/0775; C12N5/0783
Foreign References:
| JP2022045325A | 2022-03-18 | |||
| JP2022031602A | 2022-02-21 | |||
| JP2017532353A | 2017-11-02 | |||
| JP7220938B1 | 2023-02-13 |
Other References:
TROTTA R, CHEN L, CIARLARIELLO D, JOSYULA S, MAO C, COSTINEAN S, YU L, BUTCHAR J P, TRIDANDAPANI S, CROCE C M, CALIGIURI M A: "miR-155 regulates IFN-[gamma] production in natural killer cells.", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY NLD, US, vol. 119, no. 15, 12 April 2012 (2012-04-12), US , pages 3478 - 3485, XP002718287, ISSN: 1528-0020, DOI: 10.1182/blood-2011-12-398099
Attorney, Agent or Firm:
SUGAWARA Tetsuro (JP)
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