Title:
EXTRACELLULAR MATRIX (ECM)-EMBEDDED VASCULAR CHANNEL-ON-A-CHIP, AIRWAY-ON-A-CHIP, AND METHODS OF MAKING SAME
Document Type and Number:
WIPO Patent Application WO/2024/059252
Kind Code:
A3
Abstract:
An ECM-embedded vascular channel-on-a-chip includes an outer case having an internal chamber, an ECM provided within the chamber, the ECM having a cross-sectionally rounded vascular channel having a first end and a second end opposite the first end, wherein an inner surface of the channel is lined with barrier-forming endothelial cells, and an inlet conduit coupled to the first end of the channel through a first side of the outer case and an outlet conduit coupled to the second end of the channel through a second side of the outer case. Also, an airway-on-a-chip includes an airway lumen including a porous membrane, wherein mucociliated airway epithelial cells are provided on the porous membrane. The airway-on-a-chip has an ECM with embedded stromal cells. The ECM has a cross-sectionally rounded vascular channel, and the inner surface of the channel is lined with barrier-forming endothelial cells.
Inventors:
HAJIPOURAN BENAM KAMBEZ (US)
VO XUAN QUOC (US)
VO XUAN QUOC (US)
Application Number:
PCT/US2023/032847
Publication Date:
April 25, 2024
Filing Date:
September 15, 2023
Export Citation:
Assignee:
UNIV PITTSBURGH COMMONWEALTH SYS HIGHER EDUCATION (US)
International Classes:
B81C1/00; C12N5/071; B01L3/00; C12M3/02
Attorney, Agent or Firm:
LEVY, Philip E. (US)
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