Title:
ENGINEERED IMMUNE CELLS EXPRESSING A CAR AND A PLURALITY OF PROTEIN EXPRESSION BLOCKERS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/036285
Kind Code:
A3
Abstract:
The present invention provides one or more expression vectors encoding one or more of an anti-CD7 chimeric antigen receptor (CAR), an anti-CD7 protein expression blocker, a kill gene or a suicide gene, and an anti-CD3 protein expression blocker. Also provided are immune cells comprising the one or more expression vectors. Also provided are methods of producing such one or more expression vectors or immune cells. Also provided are methods of using such one or more expression vectors or immune cells for treating cancer while reducing symptoms of Graft-versus-host disease (GvHD).
Inventors:
CAMPANA DARIO (SG)
TAN YING XIM (SG)
WONG ALEX XING FAH (SG)
ZHENG SIMIN (SG)
TAN YING XIM (SG)
WONG ALEX XING FAH (SG)
ZHENG SIMIN (SG)
Application Number:
PCT/US2023/072042
Publication Date:
April 04, 2024
Filing Date:
August 10, 2023
Export Citation:
Assignee:
MEDISIX THERAPEUTICS INC (SG)
International Classes:
A61K35/17; A61P35/00; C07K14/725; C07K16/28; C12N5/0783; C12N5/10; C12N15/867; C07K14/705
Foreign References:
| US20190046571A1 | 2019-02-14 | |||
| US20210214439A1 | 2021-07-15 | |||
| US20200340016A1 | 2020-10-29 |
Attorney, Agent or Firm:
UPRIGHT, Nicholas (US)
Download PDF:
Previous Patent: GENERATION AND SELECTION OF AFFINITY REAGENTS
Next Patent: TOOTHED BELTS INCLUDING TEETH WITH ASYMMETRIC PROFILE
Next Patent: TOOTHED BELTS INCLUDING TEETH WITH ASYMMETRIC PROFILE