Title:
ELECTROPHYSIOLOGICAL EVALUATION METHOD FOR DRUG EFFICACY BASED ON IN VIVO PATCH-CLAMP TECHNIQUE
Document Type and Number:
WIPO Patent Application WO/2023/182818
Kind Code:
A1
Abstract:
Disclosed is an electrophysiological evaluation method for drug efficacy of a potassium channel modulator, based on in vivo patch-clamp technique.
Inventors:
KIM WOONG BIN (KR)
KIM SUNG YOUNG (KR)
KIM SUNG YOUNG (KR)
Application Number:
PCT/KR2023/003826
Publication Date:
September 28, 2023
Filing Date:
March 23, 2023
Export Citation:
Assignee:
IN THERAPEUTICS CO LTD (KR)
International Classes:
A61B5/00
Foreign References:
| US20150190363A1 | 2015-07-09 | |||
| US20100152116A1 | 2010-06-17 |
Other References:
PETERSEN CARL C.H.: "Whole-Cell Recording of Neuronal Membrane Potential during Behavior", NEURON, ELSEVIER, AMSTERDAM, NL, vol. 95, no. 6, 1 September 2017 (2017-09-01), AMSTERDAM, NL, pages 1266 - 1281, XP093095811, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2017.06.049
BRIAN J. WAINGER, KISKINIS EVANGELOS, MELLIN CASSIDY, WISKOW OLE, HAN STEVE S.W., SANDOE JACKSON, PEREZ NUMA P., WILLIAMS LUIS A.,: "Intrinsic Membrane Hyperexcitability of Amyotrophic Lateral Sclerosis Patient-Derived Motor Neurons", CELL REPORTS, ELSEVIER INC, US, vol. 7, no. 1, 1 April 2014 (2014-04-01), US , pages 1 - 11, XP055218701, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2014.03.019
NOGUCHI ASAKO, IKEGAYA YUJI, MATSUMOTO NOBUYOSHI: "In Vivo Whole-Cell Patch-Clamp Methods: Recent Technical Progress and Future Perspectives", SENSORS, vol. 21, no. 4, pages 1448, XP093095812, DOI: 10.3390/s21041448
BRIAN J. WAINGER, KISKINIS EVANGELOS, MELLIN CASSIDY, WISKOW OLE, HAN STEVE S.W., SANDOE JACKSON, PEREZ NUMA P., WILLIAMS LUIS A.,: "Intrinsic Membrane Hyperexcitability of Amyotrophic Lateral Sclerosis Patient-Derived Motor Neurons", CELL REPORTS, ELSEVIER INC, US, vol. 7, no. 1, 1 April 2014 (2014-04-01), US , pages 1 - 11, XP055218701, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2014.03.019
NOGUCHI ASAKO, IKEGAYA YUJI, MATSUMOTO NOBUYOSHI: "In Vivo Whole-Cell Patch-Clamp Methods: Recent Technical Progress and Future Perspectives", SENSORS, vol. 21, no. 4, pages 1448, XP093095812, DOI: 10.3390/s21041448
Attorney, Agent or Firm:
PARK, Jong Hyeok (KR)
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