Title:
DRUG DELIVERY COMPOSITION, METHOD FOR PRODUCING SAME AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/158440
Kind Code:
A1
Abstract:
The present invention provides a safe and efficacious DDS technique that achieves higher accumulation in a lesion and reduced accumulation in normal organs including the liver and, therefore, that can exert a sufficient therapeutic effect using a smaller amount of a drug. More particularly, provided is a composition that comprises carbonate apatite particles loaded with a drug, characterized in that: the average particle size of the particles is larger than 500 nm and not larger than 1000 nm; primary particles are formed in the presence of a polyethylene glycol (PEG) derivative having one or more terminal carboxylic acids, derivatives thereof or salts thereof; and the PEG derivative is incorporated into the primary particles.
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Inventors:
YAMAMOTO HIROFUMI (JP)
MORI MASAKI
AKAI SHUJI
WU XIN
MORI MASAKI
AKAI SHUJI
WU XIN
Application Number:
PCT/JP2022/001541
Publication Date:
July 28, 2022
Filing Date:
January 18, 2022
Export Citation:
Assignee:
YAMAMOTO HIROFUMI (JP)
International Classes:
A61K47/52; A61K9/14; A61K31/7088; A61K47/02; A61K47/34; A61K47/42; A61P29/00; A61P35/00
Domestic Patent References:
| WO2018199121A1 | 2018-11-01 | |||
| WO2018181877A1 | 2018-10-04 | |||
| WO2015133522A1 | 2015-09-11 | |||
| WO2020246380A1 | 2020-12-10 | |||
| WO2020036183A1 | 2020-02-20 | |||
| WO2018030338A1 | 2018-02-15 | |||
| WO2015133521A1 | 2015-09-11 | |||
| WO2018199121A1 | 2018-11-01 |
Foreign References:
| JP2021006747A | 2021-01-21 |
Other References:
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MOL CANCER THER, vol. 17, no. 5, May 2018 (2018-05-01), pages 977 - 987
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MOL CANCER THER, 2018
MOZAR FITYA SYARIFA, CHOWDHURY EZHARUL HOQUE: "PEGylation of Carbonate Apatite Nanoparticles Prevents Opsonin Binding and Enhances Tumor Accumulation of Gemcitabine", JOURNAL OF PHARMACEUTICAL SCIENCES, AMERICAN CHEMICAL SOCIETY AND AMERICAN PHARMACEUTICAL ASSOCIATION, US, vol. 107, no. 9, 1 September 2018 (2018-09-01), US , pages 2497 - 2508, XP009538479, ISSN: 0022-3549, DOI: 10.1016/j.xphs.2018.05.020
GENE, vol. 376, no. 1, 2006, pages 87 - 94
PLOSONE, vol. 10, no. 3, 4 March 2015 (2015-03-04), pages e0116022
CANCERS, vol. 12, 2020, pages 1852
JOURNAL OF ONCOLOGY, vol. 200, pages 14, Retrieved from the Internet
MOL CANCER THER., vol. 17, no. 5, May 2018 (2018-05-01), pages 977 - 987
MOL CANCER THER, vol. 17, no. 5, May 2018 (2018-05-01), pages 977 - 987
MOL THER NUCLEIC ACIDS, vol. 12, 7 September 2018 (2018-09-07), pages 658 - 671
PLOS ONE, vol. 10, no. 5, 13 May 2015 (2015-05-13), pages e0127119
MOL CANCER THER., April 2014 (2014-04-01)
BR J CANCER, vol. 122, no. 7, March 2020 (2020-03-01), pages 1037 - 1049
MOL THER NUCLEIC ACIDS., vol. 4, no. 3, 10 March 2015 (2015-03-10), pages e231
PLOS ONE, vol. 10, no. 3, 4 March 2015 (2015-03-04), pages e0116022
FRONT IMMUNOL., vol. 9, 18 April 2018 (2018-04-18), pages 783
MOL CANCER THER, 2015
MOL CANCER THER, 2018
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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