Title:
DOWNREGULATION OF MEMBRANE-BOUND PROTEINS BY RECEPTOR TAC TECHNOLOGY
Document Type and Number:
WIPO Patent Application WO/2022/053036
Kind Code:
A1
Abstract:
Provided are novel fusion proteins, nucleic acids encoding said proteins, vectors comprising said nucleic acids, compositions comprising said nucleic acids or vectors, host cells comprising said nucleic acids, vectors or compositions or pharmaceutical compositions. Provided are methods of reducing (down regulating) a target membrane-bound protein (MBP) level in a cell, methods of producing a cell having a reduced target membrane-bound protein level, or methods of treating a disease, or methods of reducing or preventing GvHD in a subject associated with the administration of one or more CAR T-cells to the subject.
Inventors:
ZHOU LI (US)
SHI FENG (US)
HARRIS MICHAEL (US)
SHI FENG (US)
HARRIS MICHAEL (US)
Application Number:
PCT/CN2021/117886
Publication Date:
March 17, 2022
Filing Date:
September 13, 2021
Export Citation:
Assignee:
SHANDONG BOAN BIOTECHNOLOGY CO LTD (CN)
BOAN BOSTON LLC (US)
BOAN BOSTON LLC (US)
International Classes:
C07K19/00; C07K14/705; C07K16/28; C12N5/10; C12N15/62
Domestic Patent References:
| WO2019032916A1 | 2019-02-14 | |||
| WO2017024318A1 | 2017-02-09 | |||
| WO2019089592A1 | 2019-05-09 | |||
| WO2020160419A1 | 2020-08-06 |
Foreign References:
| CN113088495A | 2021-07-09 | |||
| US20180086831A1 | 2018-03-29 |
Other References:
YU AIXIN, MALEK THOMAS R.: "The Proteasome Regulates Receptor-mediated Endocytosis of Interleukin-2", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 276, no. 1, 5 January 2001 (2001-01-05), US , pages 381 - 385, XP055910436, ISSN: 0021-9258, DOI: 10.1074/jbc.M007991200
See also references of EP 4178986A4
See also references of EP 4178986A4
Download PDF: