DEOPTIMIZED INFLUENZA VIRUSES AND METHODS OF TREATING CANCER

Title:

DEOPTIMIZED INFLUENZA VIRUSES AND METHODS OF TREATING CANCER

Document Type and Number:

WIPO Patent Application WO/2023/205689

Kind Code:

A3

Abstract:

The present invention provides for compositions comprising deoptimized influenza viruses and methods of using the composition for the treatment of cancer. Wherein treating a malignant tumor, comprises: administering a deoptimized influenza virus to a subject in need thereof, wherein an HA protein of the deoptimized influenza virus is encoded by a nucleic acid having a specified sequence.

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Inventors:

COLEMAN JOHN ROBERT (US)
MUELLER STEFFEN (US)
YANG CHEN (US)
WANG YING (US)
STAUFT CHARLES (US)

Application Number:

PCT/US2023/065949

Publication Date:

February 01, 2024

Filing Date:

April 19, 2023

Export Citation:

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Assignee:

CODAGENIX INC (US)

International Classes:

A61K39/12; A61K39/00; A61K39/145; A61K39/395; A61P31/14; A61P35/00; C07K16/30; C12N7/00

Foreign References:

US20210228705A1

2021-07-29

Other References:

DATABASE GenBank NCBI; "Influenza A virus (A/ Norway /3568/2009(H1N1)) hemagglutinin (HA) gene, complete cds", XP093135794
SERGEY ET AL.: "Influenza A virus (A/Tomsk/273-MA1/2010(H1N1)) segment 4 hemagglutinin (HA) gene, complete cds", GENBANK ENTRY, 7 September 2014 (2014-09-07), pages 1 - 2, Retrieved from the Internet [retrieved on 20230926]

Attorney, Agent or Firm:

HUBER, Linda B. et al. (US)

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