Title:
COMPOSITIONS AND METHODS FOR INHIBITING VIBRIO INFECTION
Document Type and Number:
WIPO Patent Application WO/2021/202632
Kind Code:
A3
Abstract:
Disclosed herein is a method for inhibiting or preventing Vibrio cholera toxin production in a subject, the method comprising enterally administering to the subject a pharmaceutically effective amount of a fatty acid dissolved or suspended in a pharmaceutically acceptable carrier, wherein the fatty acid contains 10 to 30 carbon atoms, such as an unsaturated fatty acid such as a cis-2-unsaturated fatty acid, such as a fatty acid having the formula (1) wherein n is an integer of 6-26, and the fatty acid optionally includes a second carbon-carbon double bond resulting from removal of two hydrogen atoms on adjacent carbon atoms. Also disclosed herein is a method for treating or preventing a Vibrio infection comprising administering to a subject in need of treatment an effective amount of a genetically engineered bacterium, wherein the genetically engineered bacterium comprises an exogenous nucleic acid encoding an enzyme that produces a diffusible signal factor (DSF) by introducing a cis-2 double bond to a fatty acid.
Inventors:
BOSIRE ERICK MAOSA (US)
ALTIER CRAIG (US)
ALTIER CRAIG (US)
Application Number:
PCT/US2021/025039
Publication Date:
November 11, 2021
Filing Date:
March 31, 2021
Export Citation:
Assignee:
UNIV CORNELL (US)
International Classes:
C07C57/03; A61P31/04; C07C51/377
Foreign References:
| US20130131172A1 | 2013-05-23 |
Other References:
MARQUES ET AL.: "Control of Biofilms with the Fatty Acid Signaling Molecule cis-2-Decenoic Acid", PHARMACEUTICALS, vol. 8, no. 4, 25 November 2015 (2015-11-25), pages 816 - 835, XP055793572, DOI: 10.3390/ph8040816
Attorney, Agent or Firm:
GROLZ, Edward W. (US)
Download PDF: