Title:
COMPOSITIONS AND METHOD OF USE OF MUTANT ACE2 DECOY VARIANTS
Document Type and Number:
WIPO Patent Application WO/2024/030962
Kind Code:
A3
Abstract:
Compositions are provided containing at least one mRNA sequence encoding a mutant soluble human Ace2 (hAce2) protein useful in preventing infection with betacoronaviruses, including SARS-CoV2 is provided, as are compositions useful in treating disease associated with betacoronavirus, including, e.g, COVID-19. Compositions containing the mRNA in a cocktail with other mRNA encoding soluble hAce2 mutant proteins and/or protein-based therapeutics are provided. Also provided are compositions containing these proteins formulated for intranasal and/or intrapulmonary delivery, methods of making same and assays.
Inventors:
SIDRANE JENNY A (US)
WILSON JAMES M (US)
SIMS JOSHUA JOYNER (US)
WILSON JAMES M (US)
SIMS JOSHUA JOYNER (US)
Application Number:
PCT/US2023/071524
Publication Date:
April 25, 2024
Filing Date:
August 02, 2023
Export Citation:
Assignee:
UNIV PENNSYLVANIA (US)
International Classes:
C12N15/00; A61P31/14; C07K14/165; C07K7/14; C07K14/47
Attorney, Agent or Firm:
KODROFF, Cathy et al. (US)
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