Title:
COMPOSITION CONTAINING OSMOTIN PROTEIN AS ACTIVE INGREDIENT FOR PREVENTION, ALLEVIATION, OR TREATMENT OF PARKINSON'S DISEASE
Document Type and Number:
WIPO Patent Application WO/2024/038934
Kind Code:
A1
Abstract:
The present invention relates to a composition containing osmotin protein as an active ingredient for the prevention, alleviation, or treatment of Parkinson's disease. The osmotin protein has the effects of: alleviating behavioral and motor deficiencies induced by MPTP/α-synuclein; protecting dopamine-active neurons; regulating the expression of neuroinflammation-related proteins; suppressing MPTP/α-synuclein-induced cell death; mitigating cellular damage from the overexpression of α-synuclein (A53T); activating AMPK, and subsequently reducing the accumulation of α-synuclein through autophagy; modulating the dendritic composite structure; increasing spine density in pyramidal neurons; alleviating cognitive deficits; and restoring the expression of synaptic markers. Hence, the composition can be beneficially used as a health functional food or medicine for the prevention, improvement, or treatment of Parkinson's disease.
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Inventors:
KIM MYEONG OK (KR)
PARK JUN SUNG (KR)
CHOE KYONGHWAN (KR)
PARK TAE JU (KR)
PARK JUN SUNG (KR)
CHOE KYONGHWAN (KR)
PARK TAE JU (KR)
Application Number:
PCT/KR2022/012416
Publication Date:
February 22, 2024
Filing Date:
August 19, 2022
Export Citation:
Assignee:
NAT UNIV GYEONGSANG IACF (KR)
International Classes:
A23L33/18; A23L2/38; A23L33/175; A23P10/28; A23P10/30; A61K38/16; A61P25/16
Domestic Patent References:
| WO2016043354A1 | 2016-03-24 |
Foreign References:
| KR20160108191A | 2016-09-19 | |||
| US20090298741A1 | 2009-12-03 | |||
| KR20160072835A | 2016-06-23 | |||
| KR20220120882A | 2022-08-31 | |||
| KR101308232B1 | 2013-11-06 |
Other References:
SINGH, NELSON D.E, KUHN D, HASEGAWA P.M, BRESSAN R.A: "Molecular cloning of osmotin and regulation of its expression by ABA and adaptation to low water potential", PLANT PHYSIOLOGY, AMERICAN SOCIETY OF PLANT PHYSIOLOGISTS, ROCKVILLE, MD, USA, vol. 90, no. 3, 1 July 1989 (1989-07-01), Rockville, Md, USA , pages 1096 - 1101, XP093139617, ISSN: 0032-0889, DOI: 10.1104/pp.90.3.1096
Attorney, Agent or Firm:
CHOI, Kyu Whan (KR)
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