Title:
CHIRAL GAMMA LACTAM DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2024/049236
Kind Code:
A1
Abstract:
The present invention relates to: a method for preparing a chiral gamma lactam derivative or a pharmaceutically acceptable salt thereof by using a chiral organocatalytic compound; and a composition for preventing, alleviating or treating muscle diseases, mental diseases, or neurodegenerative diseases, comprising the derivative or the pharmaceutically acceptable salt thereof. The chiral gamma lactam derivative or the pharmaceutically acceptable salt thereof, of the present invention, has an effect of inhibiting MAO-B and MSTN, targets D1-mClu5, and can be used in the prevention, alleviation, or treatment of muscle diseases including sarcopenia, mental diseases including depression, neurodegenerative diseases including Parkinson's disease, and the like.
Inventors:
SHIM JAE HO (KR)
Application Number:
PCT/KR2023/012986
Publication Date:
March 07, 2024
Filing Date:
August 31, 2023
Export Citation:
Assignee:
UNIV KOREA RES & BUS FOUND (KR)
International Classes:
C07D207/26; A61K31/4015; A61P25/16; B01J31/02
Domestic Patent References:
| WO2001062726A2 | 2001-08-30 | |||
| WO2007104780A2 | 2007-09-20 |
Foreign References:
| KR20190103944A | 2019-09-05 | |||
| EP3127539A1 | 2017-02-08 | |||
| JP2007332129A | 2007-12-27 |
Other References:
SHIM JAE HO, HONG YEONSUN, KIM JI HAE, KIM HYEON SOO, HA DEOK-CHAN: "Organocatalytic Asymmetric Michael Addition in Aqueous Media by a Hydrogen-Bonding Catalyst and Application for Inhibitors of GABAB Receptor", CATALYSTS, M D P I AG, CH, vol. 11, no. 9, 21 September 2021 (2021-09-21), CH , pages 1134, XP093145085, ISSN: 2073-4344, DOI: 10.3390/catal11091134
Attorney, Agent or Firm:
MUHANN PATENT & LAW FIRM (KR)
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