Title:
CHIMERIC ANTIGEN RECEPTOR-EXPRESSING CELL THAT TARGETS EGFR
Document Type and Number:
WIPO Patent Application WO/2023/234330
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing an EGFR CAR-T cell which is expected to be effective against a tumor in which an EGFR is expressed. The present invention provides: a polynucleotide encoding a chimeric antigen receptor (chimeric antigen receptor: CAR) protein comprising a target binding domain capable of binding to an epidermal growth factor receptor (EGFR), a transmembrane domain and an intracellular signaling domain, in which the target binding domain is a ligand of an EGFR; a vector carrying the polynucleotide; and a genetically modified cell into which the polypeptide or the vector has been introduced.
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Inventors:
NAKAZAWA YOZO (JP)
HIRABAYASHI KOICHI (JP)
CHINSUWAN THANYAVI (JP)
HASEGAWA AIKO (JP)
YAGYU SHIGEKI (JP)
HIRABAYASHI KOICHI (JP)
CHINSUWAN THANYAVI (JP)
HASEGAWA AIKO (JP)
YAGYU SHIGEKI (JP)
Application Number:
PCT/JP2023/020214
Publication Date:
December 07, 2023
Filing Date:
May 31, 2023
Export Citation:
Assignee:
UNIV SHINSHU (JP)
KYOTO PREFECTURAL PUBLIC UNIV CORP (JP)
KYOTO PREFECTURAL PUBLIC UNIV CORP (JP)
International Classes:
C12N15/62; A61K35/12; A61K35/17; A61K48/00; A61P1/00; A61P1/04; A61P1/16; A61P1/18; A61P11/00; A61P15/00; A61P17/00; A61P25/00; A61P35/00; A61P43/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/63; C12P21/02
Other References:
DAVIES D M, FOSTER J, VAN DER STEGEN S J, PARENTE-PEREIRA A C, CHIAPERO-STANKE L, DELINASSIOS G J, BURBRIDGE S E, KAO V, LIU Z, BO: "Flexible targeting of ErbB dimers that drive tumorigenesis by using genetically engineered T cells.", MOLECULAR MEDICINE, FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH, WASHINGTON , DC, vol. 18, no. 1, 1 January 2012 (2012-01-01), Washington , DC , pages 565 - 576, XP055240599, ISSN: 1076-1551, DOI: 10.2119/molmed.2011.00493
PARENTE-PEREIRA ANA C., WHILDING LYNSEY M., BREWIG NANCY, VAN DER STEGEN SJOUKJE J. C., DAVIES DAVID M., WILKIE SCOTT, VAN SCHALKW: "Synergistic Chemoimmunotherapy of Epithelial Ovarian Cancer Using ErbB-Retargeted T Cells Combined with Carboplatin", THE JOURNAL OF IMMUNOLOGY, WILLIAMS & WILKINS CO., US, vol. 191, no. 5, 1 September 2013 (2013-09-01), US , pages 2437 - 2445, XP093116995, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1301119
LARCOMBE-YOUNG DANIEL, PAPA SOPHIE, MAHER JOHN: "PanErbB-targeted CAR T-cell immunotherapy of head and neck cancer", EXPERT OPINION ON BIOLOGICAL THERAPY, INFORMA HEALTHCARE, vol. 20, no. 9, 1 September 2020 (2020-09-01), pages 965 - 970, XP093116998, ISSN: 1471-2598, DOI: 10.1080/14712598.2020.1786531
PARENTE-PEREIRA ANA C., WHILDING LYNSEY M., BREWIG NANCY, VAN DER STEGEN SJOUKJE J. C., DAVIES DAVID M., WILKIE SCOTT, VAN SCHALKW: "Synergistic Chemoimmunotherapy of Epithelial Ovarian Cancer Using ErbB-Retargeted T Cells Combined with Carboplatin", THE JOURNAL OF IMMUNOLOGY, WILLIAMS & WILKINS CO., US, vol. 191, no. 5, 1 September 2013 (2013-09-01), US , pages 2437 - 2445, XP093116995, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1301119
LARCOMBE-YOUNG DANIEL, PAPA SOPHIE, MAHER JOHN: "PanErbB-targeted CAR T-cell immunotherapy of head and neck cancer", EXPERT OPINION ON BIOLOGICAL THERAPY, INFORMA HEALTHCARE, vol. 20, no. 9, 1 September 2020 (2020-09-01), pages 965 - 970, XP093116998, ISSN: 1471-2598, DOI: 10.1080/14712598.2020.1786531
Attorney, Agent or Firm:
HIRAKI & ASSOCIATES (JP)
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