Title:
CELL GROWTH SUPPLEMENTS USING DAIRY-BASED MATERIALS
Document Type and Number:
WIPO Patent Application WO/2024/010727
Kind Code:
A3
Abstract:
The present disclosure relates to cell growth supplements using dairy-based materials for cell culture and other applications. Some embodiments are directed to sequentially culturing cells in a culture medium comprising factors to increase the relative size and/or density of the cells in the culture, e.g., whey protein. Other aspects of the disclosure relate to obtaining a milk product to produce the dairy-based material, e.g., milking a nursing mammal, milk-producing organoids, bacterial expression systems, etc. In some embodiments, the disclosure relates to techniques for isolating a whey protein from the milk product.
Inventors:
AHADIAN SAMAD (US)
HUANG WEI (US)
KHADEMHOSSEINI ALIREZA (US)
HUANG WEI (US)
KHADEMHOSSEINI ALIREZA (US)
Application Number:
PCT/US2023/026523
Publication Date:
April 18, 2024
Filing Date:
June 29, 2023
Export Citation:
Assignee:
TERASAKI INST FOR BIOMEDICAL INNOVATION (US)
International Classes:
C12N5/07; A23C9/15; A61K35/20; A61K38/01; C07K14/65
Foreign References:
| US5164370A | 1992-11-17 |
Other References:
ANHENG WANG: "High-throughput fabrication of hepatic cell clusteroids with enhanced growth and functionality for tissue engineering applications", MATERIALS ADVANCES, THE ROYAL SOCIETY OF CHEMISTRY, vol. 1, no. 8, 16 November 2020 (2020-11-16), pages 3022 - 3032, XP093163370, ISSN: 2633-5409, DOI: 10.1039/D0MA00635A
IBRINI, FADEL, CHANA, BRUNSKILL, WAGNER, JOHNSON, EL NAHAS: "Albumin-Induced Epithelial Mesenchymal Transformation", NEPHRON EXPERIMENTAL NEPHROLOGY, S. KARGER AG, CH, vol. 120, no. 3, CH , pages e91 - e102, XP009554153, ISSN: 1660-2129, Retrieved from the Internet DOI: 10.1159/000336822
TINA S NIELSEN: "Proliferative effect of whey from cows' milk obtained at two different stages of pregnancy measured in MCF-7 cells", JOURNAL OF DAIRY RESEARCH, CAMBRIDGE UNIVERSITY PRESS, CAMBRIDGE, GB, vol. 79, no. 1, 1 February 2012 (2012-02-01), GB , pages 33 - 38, XP093163375, ISSN: 0022-0299, DOI: 10.1017/S0022029911000689
IBRINI, FADEL, CHANA, BRUNSKILL, WAGNER, JOHNSON, EL NAHAS: "Albumin-Induced Epithelial Mesenchymal Transformation", NEPHRON EXPERIMENTAL NEPHROLOGY, S. KARGER AG, CH, vol. 120, no. 3, CH , pages e91 - e102, XP009554153, ISSN: 1660-2129, Retrieved from the Internet
TINA S NIELSEN: "Proliferative effect of whey from cows' milk obtained at two different stages of pregnancy measured in MCF-7 cells", JOURNAL OF DAIRY RESEARCH, CAMBRIDGE UNIVERSITY PRESS, CAMBRIDGE, GB, vol. 79, no. 1, 1 February 2012 (2012-02-01), GB , pages 33 - 38, XP093163375, ISSN: 0022-0299, DOI: 10.1017/S0022029911000689
Attorney, Agent or Firm:
CHEN, Tani et al. (US)
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