Title:
CDK2 INHIBITORS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/039903
Kind Code:
A3
Abstract:
The present invention provides bicyclic and monocyclic heterocyclic amine compounds, with sulfoxide, sulfone or sulfonamide functionality, useful as inhibitors of cyclin-dependent kinase 2 (CDK2), as well as inhibitors of CDK2 and cyclin E1 (CCNE1) protein. Further disclosed are compositions thereof, and methods of using the same for treating a variety of diseases, disorders or conditions, associated with regulation of CDK2 protein, including, but not limited to, cancers that are characterized by amplification or overexpression of CCNEI.
Inventors:
COLLIER PHILIP (US)
ZHENG XIAOZHANG (US)
ZHU XIAO (US)
FORD MELISSA (US)
WEISS MATTHEW (US)
AVERSA ROBERT (US)
MAHASENAN KIRAN VIJAYAKUMARI (US)
ZHANG YI (US)
ZHENG XIAOZHANG (US)
ZHU XIAO (US)
FORD MELISSA (US)
WEISS MATTHEW (US)
AVERSA ROBERT (US)
MAHASENAN KIRAN VIJAYAKUMARI (US)
ZHANG YI (US)
Application Number:
PCT/US2023/030721
Publication Date:
April 18, 2024
Filing Date:
August 21, 2023
Export Citation:
Assignee:
KYMERA THERAPEUTICS INC (US)
International Classes:
C07D471/04; A61K31/519; A61K31/545; C07D401/14; C07D487/04
Foreign References:
| US20210107901A1 | 2021-04-15 | |||
| US20200399273A1 | 2020-12-24 | |||
| US20200392142A1 | 2020-12-17 |
Attorney, Agent or Firm:
REID, Andrea, L.C. et al. (US)
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