Title:
CAR T CELL COMPOSITIONS FOR TREATMENT OF CANCER
Document Type and Number:
WIPO Patent Application WO/2024/059821
Kind Code:
A3
Abstract:
Compositions for the treatment of cancer that include CAR T cells in which expression of FOXO3 expression is silenced are disclosed in various aspects. In various other aspects, methods for preventing or delaying a development of dysfunction in a CAR T cell associated with chronic antigen stimulation are described that include silencing the expression of FOXO3 by the CAR T cell.
Inventors:
SINGH NATHAN (US)
Application Number:
PCT/US2023/074347
Publication Date:
April 25, 2024
Filing Date:
September 15, 2023
Export Citation:
Assignee:
WASHINGTON UNIVERSITY ST LOUIS (US)
International Classes:
C12N5/0783; A61K35/17; C07K16/28
Attorney, Agent or Firm:
VANENGELEN, Catherine E. (US)
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