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Title:
BILE ACID METABOLIZING BACTERIUM FOR PREVENTING AND TREATING INFLAMMATORY BOWEL DISEASE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/066079
Kind Code:
A1
Abstract:
The present invention provides a bile acid metabolizing bacterium for preventing and treating an inflammatory bowel disease and use thereof. The present invention provides a bacterium which comprises any one, two or three of the following strains: Clostridium sp. with the collection number of GDMCC No: 62707, Eubacterium limosum with the collection number of GDMCC No: 62708, and Bacteroides ovatus with the collection number of GDMCC No: 62709. The bacterium of the present invention can convert primary bile acids into secondary bile acids, ameliorating the inflammation symptoms of DSS-induced ulcerative colitis in mice.

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Inventors:
DAI LEI (CN)
Application Number:
PCT/CN2022/139762
Publication Date:
April 04, 2024
Filing Date:
December 16, 2022
Export Citation:
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Assignee:
SHENZHEN INST OF ADV TECH CAS (CN)
International Classes:
C12N1/20; A61K35/74; A61P1/04; C12R1/01; C12R1/145
Domestic Patent References:
WO2021137237A12021-07-08
WO2022014893A12022-01-20
WO2022092964A12022-05-05
Foreign References:
CN112118852A2020-12-22
CN110023484A2019-07-16
Attorney, Agent or Firm:
BEIJING SANYOU INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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