Title:
APPLICATION OF MIXED N-HETEROCYCLIC CARBENE-BASED NICKEL (II) COMPLEX IN REACTION FOR SYNTHESIZING 2-LINEAR ALKYLBENZOTHIAZOLE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2021/212734
Kind Code:
A1
Abstract:
Disclosed in the present invention are an application of a mixed N-heterocyclic carbene-based nickel (II) complex in a reaction for synthesizing a 2-linear alkylbenzothiazole compound, and a method for synthesizing a 2-linear alkylbenzothiazole compound. A 2-linear alkylbenzothiazole compound is synthesized by a hydroheteroarylation reaction of an aliphatic α-olefin and a benzothiazole compound in the presence of magnesium by using as a catalyst a mixed nickel (II) complex having the molecular formula Ni[P(OEt) 3](RNCHCHNR)C]Br 2 , [R being 2,6-bis(diphenylmethyl)-4-methoxyphenyl]. Compared with existing methods, the present invention avoids the use of expensive monovalent rhodium complexes, and provides a novel method for preparing a 2-linear alkylbenzothiazole compound by means of the hydroheteroarylation reaction of an aliphatic α-olefin by using a divalent nickel catalyst.
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Inventors:
SUN HONGMEI (CN)
SHUI YU (CN)
SHUI YU (CN)
Application Number:
PCT/CN2020/116941
Publication Date:
October 28, 2021
Filing Date:
September 22, 2020
Export Citation:
Assignee:
UNIV SOOCHOW (CN)
International Classes:
B01J31/22; B01J31/18; C07D277/64
Foreign References:
| CN111420709A | 2020-07-17 | |||
| CN108002966A | 2018-05-08 | |||
| CN110330535A | 2019-10-15 | |||
| US20120095180A1 | 2012-04-19 |
Other References:
DONG ZHE, REN ZHI, THOMPSON SAMUEL J., XU YAN, DONG GUANGBIN: "Transition-Metal-Catalyzed C–H Alkylation Using Alkenes", CHEMICAL REVIEWS, AMERICAN CHEMICAL SOCIETY, US, vol. 117, no. 13, 12 July 2017 (2017-07-12), US , pages 9333 - 9403, XP055860045, ISSN: 0009-2665, DOI: 10.1021/acs.chemrev.6b00574
Attorney, Agent or Firm:
SUZHOU CREATOR PATENT AND TRADEMARK AGENCY, LTD (CN)
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