Title:
ANTIVIRAL NUCLEIC ACID
Document Type and Number:
WIPO Patent Application WO/2022/230974
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing: an antiviral nucleic acid, etc., against SARS-CoV-2 SARS-CoV-2, SARS-CoV-1, or MERS-CoV; and/or a method for treating and/or preventing a viral infection using the nucleic acid, etc. The present invention relates to an antiviral nucleic acid that targets a sequence in at least one target region selected from the group consisting of the 5' UTR region, nsp3 region, 3C-like proteinase region, nsp9 region, RNA-dependent RNA polymerase region, helicase region, 3'-to-5' exonuclease region, 2'-O-ribose methyltransferase region, S region including S1 region and S2 region, E region, M region, and N region in the genomic RNA of SARS-CoV-2, or a pharmacologically acceptable salt thereof or a hydrate of these, etc., wherein the virus is SARS-CoV-2, SARS-CoV-1, or MERS-CoV.
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Inventors:
NAKAGAWA SHINICHIRO (JP)
TAGAYA MITSUHIRO (JP)
HIMOTO TAKUYA (JP)
KAMITANI WATARU (JP)
TAGAYA MITSUHIRO (JP)
HIMOTO TAKUYA (JP)
KAMITANI WATARU (JP)
Application Number:
PCT/JP2022/019273
Publication Date:
November 03, 2022
Filing Date:
April 28, 2022
Export Citation:
Assignee:
NIPPON SHINYAKU CO LTD (JP)
UNIV GUNMA NAT UNIV CORP (JP)
UNIV GUNMA NAT UNIV CORP (JP)
International Classes:
C12N15/113; A61K31/7088; A61K31/712; A61K31/7125; A61K31/713; A61K48/00; A61P31/12; C12N15/63
Domestic Patent References:
| WO2021224918A1 | 2021-11-11 | |||
| WO2021241040A1 | 2021-12-02 |
Foreign References:
| CN111330003A | 2020-06-26 | |||
| CN112111489A | 2020-12-22 | |||
| CN111321142A | 2020-06-23 | |||
| CN111139241A | 2020-05-12 | |||
| CN111139242A | 2020-05-12 | |||
| JP2006129594W | ||||
| JP2006038608W |
Other References:
WU, F. et al. A new coronavirus associated with human respiratory disease in China. Nature (2020) vol. 579, pp. 265-269, Methods, Extended Data fig. 1-9, Supplementary Information, Supplementary Tables 1-8
DATABASE Nucleotide 18 July 2020 (2020-07-18), "Severe acute respiratory syndrome coronavirus 2 isolate Wuhan-Hu-1, co", XP055864394, retrieved from NCBI Database accession no. NC_045512
WORLD HEALTH ORGANIZATION (WHO) (PRESS RELEASE, 11 March 2020 (2020-03-11)
NAT MICROBIOL., vol. 5, no. 4, April 2020 (2020-04-01), pages 536 - 544
ENYA ET AL., BIOORGANIC & MEDICINAL CHEMISTRY, vol. 18, 2008, pages 9154 - 9160
NUCLEIC ACIDS RESEARCH, vol. 12, 1984, pages 4539 - 4557
SCIENCE, vol. 227, no. 4693, 1985, pages 1435 - 1441
KARLINALTSCHUL, PROC. NATL. ACAD. SCI. USA, 1990, pages 872264 - 2268
PROC NATL ACAD SCI USA, vol. 90, 1993, pages 5873
ALTSCHUL SF ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403
TERADA ET AL., J VIROL, vol. 93, 2019, pages e01208 - 19, Retrieved from the Internet
DATABASE Nucleotide 18 July 2020 (2020-07-18), "Severe acute respiratory syndrome coronavirus 2 isolate Wuhan-Hu-1, co", XP055864394, retrieved from NCBI Database accession no. NC_045512
WORLD HEALTH ORGANIZATION (WHO) (PRESS RELEASE, 11 March 2020 (2020-03-11)
NAT MICROBIOL., vol. 5, no. 4, April 2020 (2020-04-01), pages 536 - 544
ENYA ET AL., BIOORGANIC & MEDICINAL CHEMISTRY, vol. 18, 2008, pages 9154 - 9160
NUCLEIC ACIDS RESEARCH, vol. 12, 1984, pages 4539 - 4557
SCIENCE, vol. 227, no. 4693, 1985, pages 1435 - 1441
KARLINALTSCHUL, PROC. NATL. ACAD. SCI. USA, 1990, pages 872264 - 2268
PROC NATL ACAD SCI USA, vol. 90, 1993, pages 5873
ALTSCHUL SF ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403
TERADA ET AL., J VIROL, vol. 93, 2019, pages e01208 - 19, Retrieved from the Internet
Attorney, Agent or Firm:
KOBAYASHI Hiroshi et al. (JP)
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