Title:
ANTIBODY-DRUG CONJUGATE, PREPARATION METHOD THEREFOR AND USE THEREOF IN RESISTING TUMORS
Document Type and Number:
WIPO Patent Application WO/2024/083166
Kind Code:
A1
Abstract:
An antibody-drug conjugate, a preparation method therefor and the use thereof in resisting tumors, which specifically relates to an anti-HER3 antibody or an antigen-binding fragment thereof, and an antibody-drug conjugate linked to the antibody. The antibody-drug conjugate has a structure as shown in Ab-(L-D)n, and is covalently linked with an effective load with cytotoxicity via a linker. The anti-HER3 antibody or the antigen-binding fragment thereof and the antibody-drug conjugate have a use in the preparation of a therapeutic agent for diagnosing, preventing and treating tumor diseases.
Inventors:
MENG XUN (CN)
WENG WEINING (CN)
WENG WEINING (CN)
Application Number:
PCT/CN2023/125269
Publication Date:
April 25, 2024
Filing Date:
October 18, 2023
Export Citation:
Assignee:
MULTITUDE THERAPEUTICS INC (CN)
International Classes:
C07K16/32; A61K39/395; A61K47/68; A61P35/00; C07K16/28; C07K16/30
Domestic Patent References:
| WO2022078425A1 | 2022-04-21 | |||
| WO2012019024A2 | 2012-02-09 | |||
| WO2019241893A2 | 2019-12-26 |
Foreign References:
| CN106163559A | 2016-11-23 | |||
| CN104093743A | 2014-10-08 |
Other References:
KUMIKO KOYAMA, HIROKAZU ISHIKAWA , MANABU ABE, YOSHINOBU SHIOSE , SUGURU UENO , YANG QIU , KENJI NAKAMARU , MASATO MURAKAMI: "Patritumab deruxtecan (HER3-DXd), a novel HER3 directed antibody drug conjugate, exhibits in vitro activity against breast cancer cells expressing HER3 mutations with and without HER2 overexpression", PLOS ONE, vol. 17, no. 5, 3 May 2022 (2022-05-03), US , pages 1 - 10, XP093160639, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0267027
SHIGEHIRO KOGANEMARU; YASUTOSHI KUBOKI; YOSHIKATSU KOGA; TAKASHI KOJIMA; MAYUMI YAMAUCHI; NAOYUKI MAEDA; TAKASHI KAGARI; KENJI HIR: "U3-1402, a Novel HER3-Targeting Antibody–Drug Conjugate, for the Treatment of Colorectal Cancer", MOLECULAR CANCER THERAPEUTICS, vol. 18, no. 11, 1 November 2019 (2019-11-01), US , pages 2043 - 2050, XP093160642, ISSN: 1535-7163, DOI: 10.1158/1535-7163.MCT-19-0452
SHIGEHIRO KOGANEMARU; YASUTOSHI KUBOKI; YOSHIKATSU KOGA; TAKASHI KOJIMA; MAYUMI YAMAUCHI; NAOYUKI MAEDA; TAKASHI KAGARI; KENJI HIR: "U3-1402, a Novel HER3-Targeting Antibody–Drug Conjugate, for the Treatment of Colorectal Cancer", MOLECULAR CANCER THERAPEUTICS, vol. 18, no. 11, 1 November 2019 (2019-11-01), US , pages 2043 - 2050, XP093160642, ISSN: 1535-7163, DOI: 10.1158/1535-7163.MCT-19-0452
Attorney, Agent or Firm:
BEIJING HAN KUN LAW OFFICES (CN)
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