Title:
ANTI-INFLAMMATORY AGENT, TNF-α PRODUCTION INHIBITOR, INTERLEUKIN-10 PRODUCTION PROMOTOR, SKIN EXTERNAL APPLICATION COMPOSITION, FOOD OR BEVERAGE COMPOSITION, METHOD FOR PREVENTING, AMELIORATING, OR TREATING INFLAMMATORY DISEASES, AND USE OF PLANT-DERIVED POLYAMINE-CONTAINING EXTRACT FOR MANUFACTURING ANTI-INFLAMMATORY AGENT
Document Type and Number:
WIPO Patent Application WO/2024/085105
Kind Code:
A1
Abstract:
A purpose of the present invention is to provide an anti-inflammatory agent, a TNF-α production inhibitor, and an IL-10 production promotor which contain a plant-derived active ingredient. Another purpose of the present invention is to provide a food or beverage composition and a skin external application composition which contain a plant-derived active ingredient and which have an anti-inflammatory effect. The anti-inflammatory agent, the TNF-α production inhibitor, and the IL-10 production promotor contain a plant-derived polyamine-containing extract. The plant-derived polyamine-containing extract includes a less-than-1 kDa fraction. The less-than-1 kDa fraction contains an active ingredient. The food or beverage composition and the skin external application composition contain the anti-inflammatory agent.
Inventors:
TOYAMA KINUKA (JP)
NISHIMURA KENGO (JP)
NISHIMURA KENGO (JP)
Application Number:
PCT/JP2023/037358
Publication Date:
April 25, 2024
Filing Date:
October 16, 2023
Export Citation:
Assignee:
TOYO BOSEKI (JP)
International Classes:
A61K36/48; A23L2/52; A23L33/105; A61K31/132; A61K36/899; A61P29/00
Domestic Patent References:
| WO2019159588A1 | 2019-08-22 |
Foreign References:
| JP2021075495A | 2021-05-20 |
Other References:
CLAUDIA SCHWARZ, GLORIA S. BENSON, NORA HORN, KATHARINA WURDACK, ULRIKE GRITTNER, RALPH SCHILLING, STEFANIE MÄRSCHENZ, THERESA KÖB: "Effects of Spermidine Supplementation on Cognition and Biomarkers in Older Adults With Subjective Cognitive Decline : A Randomized Clinical Trial", JAMA NETWORK OPEN, JAMA NETWORK, vol. 5, no. 5, 2 May 2022 (2022-05-02), pages e2213875, XP093161591, ISSN: 2574-3805, DOI: 10.1001/jamanetworkopen.2022.13875
HIROYUKI KAWAMURA, KIMIKO SENO, TAKEHISA KUMAGAI, TOSHIYUKI WATANABE, KOHJI YAMAKI, TOJIRO TSUSHID: "Effects of Lactobacillus and Some Vegetable Homogenates on Phagocytosis of Rat Peritoneal Macrophages", NIPPON SHOKUHIN KAGAKU KOGAKU KAISHI, vol. 47, no. 6, 1 January 2000 (2000-01-01), pages 465 - 469, XP093161742, DOI: 10.3136/nskkk.47.465
SUGIYAMA, TOSHIHIRO: "Search of a natural substance with the hair growth using a hair follicle organ culture", ANNUAL REPORT OF COSMETOLOGY, vol. 21, 2013, pages 19 - 23
AYAO YAMAMOTO, SACHIO OGATA, MASATO KANAMORI, SHOZO NAKAZAWA, AKIYOSHI TSUJI: "Studies on anti-tumor effects of extracts from bamboo grass", JOURNAL OF THE KYORIN MEDICAL SOCIETY, vol. 2, no. 2, 31 December 1971 (1971-12-31), pages 73 - 84, XP009554123, ISSN: 0368-5829, DOI: 10.11434/kyorinmed.2.73
SODA, KUNIYASU: "Potential of polyamines as anti-inflammatory drugs and antiallergic agent", BIOTHERAPY, vol. 20, no. 1, 2006, pages 79
MINGMING XUE: "Effects of Tumor Necrosis Factor α (TNF-α) and Interleukina 10 (IL-10) on Intercellular Cell Adhesion Molecule-1 (ICAM-1) and Cluster of Differentiation 31 (CD31) in Human Coronary Artery Endothelial Cells", MEDICAL SCIENCE MONITOR. INTERNATIONAL MEDICAL JOURNAL FOR EXPERIMENTAL AND CLINICAL RESEARCH, MEDICAL SCIENCE INTERNATIONAL LTD., vol. 24, 1 January 2018 (2018-01-01), pages 4433 - 4439, XP093161593, ISSN: 1643-3750, DOI: 10.12659/MSM.906838
HIROYUKI KAWAMURA, KIMIKO SENO, TAKEHISA KUMAGAI, TOSHIYUKI WATANABE, KOHJI YAMAKI, TOJIRO TSUSHID: "Effects of Lactobacillus and Some Vegetable Homogenates on Phagocytosis of Rat Peritoneal Macrophages", NIPPON SHOKUHIN KAGAKU KOGAKU KAISHI, vol. 47, no. 6, 1 January 2000 (2000-01-01), pages 465 - 469, XP093161742, DOI: 10.3136/nskkk.47.465
SUGIYAMA, TOSHIHIRO: "Search of a natural substance with the hair growth using a hair follicle organ culture", ANNUAL REPORT OF COSMETOLOGY, vol. 21, 2013, pages 19 - 23
AYAO YAMAMOTO, SACHIO OGATA, MASATO KANAMORI, SHOZO NAKAZAWA, AKIYOSHI TSUJI: "Studies on anti-tumor effects of extracts from bamboo grass", JOURNAL OF THE KYORIN MEDICAL SOCIETY, vol. 2, no. 2, 31 December 1971 (1971-12-31), pages 73 - 84, XP009554123, ISSN: 0368-5829, DOI: 10.11434/kyorinmed.2.73
SODA, KUNIYASU: "Potential of polyamines as anti-inflammatory drugs and antiallergic agent", BIOTHERAPY, vol. 20, no. 1, 2006, pages 79
MINGMING XUE: "Effects of Tumor Necrosis Factor α (TNF-α) and Interleukina 10 (IL-10) on Intercellular Cell Adhesion Molecule-1 (ICAM-1) and Cluster of Differentiation 31 (CD31) in Human Coronary Artery Endothelial Cells", MEDICAL SCIENCE MONITOR. INTERNATIONAL MEDICAL JOURNAL FOR EXPERIMENTAL AND CLINICAL RESEARCH, MEDICAL SCIENCE INTERNATIONAL LTD., vol. 24, 1 January 2018 (2018-01-01), pages 4433 - 4439, XP093161593, ISSN: 1643-3750, DOI: 10.12659/MSM.906838
Attorney, Agent or Firm:
UNIUS PATENT ATTORNEYS OFFICE (JP)
Download PDF:
Previous Patent: POLYARYL ETHER KETONE AND METHOD FOR PRODUCING SAME, AND RESIN COMPOSITION
Next Patent: ELECTRONIC DEVICE
Next Patent: ELECTRONIC DEVICE