Title:
ANTI-EGFR AND CMET BISPECIFIC CHIMERIC ANTIGEN RECEPTOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/051641
Kind Code:
A1
Abstract:
The present invention provides an anti-EGFR and cMet bispecific chimeric antigen receptor and use thereof. Specifically, the present invention provides an immune cell expressing a first CAR and a second CAR, the first CAR targets a first tumor cell marker, and the second CAR targets a second tumor cell marker. The first CAR and the second CAR of the present invention recognize the corresponding tumor cell markers at the same time, so that the immune cell can be fully activated to enhance the targeting specificity and exert the anti-tumor effect, and the on-target/off-tumor toxicity is reduced, thereby improving the safety of cell therapy.
Inventors:
GAO MINGMING (CN)
SHEN HAO (CN)
JIN LIYUAN (CN)
ZHANG WEIWEI (CN)
SHEN HAO (CN)
JIN LIYUAN (CN)
ZHANG WEIWEI (CN)
Application Number:
PCT/CN2023/116708
Publication Date:
March 14, 2024
Filing Date:
September 04, 2023
Export Citation:
Assignee:
FOSUN KITE BIOTECHNOLOGY CO LTD (CN)
International Classes:
C12N5/10; A61K39/00; A61P35/00; C07K19/00
Domestic Patent References:
| WO2020172177A1 | 2020-08-27 |
Foreign References:
| CN109161532A | 2019-01-08 | |||
| CN109423495A | 2019-03-05 |
Other References:
MENG, TAO; ZENG, XIANGYUE; JIN, BO: "Parallel CAR-T Cells Targeting HER2 and CLDN18.2 Reduce the Off Target Effect on Gastric Cancer", ACTA UNIVERSITATIS MEDICINALIS ANHUI, CN, vol. 57, no. 10, 30 August 2022 (2022-08-30), CN, pages 1595 - 1601, XP009553896, ISSN: 1000-1492, DOI: 10.19405/j.cnki.issn1000-1492.2022.10.016
ZENG WANYING, ZHANG QING, ZHU YANGMIN, OU RUIMING, PENG LIANG, WANG BAOLEI, SHEN HUIJUAN, LIU ZHI, LU LISHENG, ZHANG PUMIN, LIU SH: "Engineering Novel CD19/CD22 Dual-Target CAR-T Cells for Improved Anti-Tumor Activity", CANCER INVESTIGATION., TAYLOR & FRANCIS INC., US, vol. 40, no. 3, 25 November 2021 (2021-11-25), US , pages 282 - 292, XP009553897, ISSN: 0735-7907, DOI: 10.1080/07357907.2021.2005798
ZENG WANYING, ZHANG QING, ZHU YANGMIN, OU RUIMING, PENG LIANG, WANG BAOLEI, SHEN HUIJUAN, LIU ZHI, LU LISHENG, ZHANG PUMIN, LIU SH: "Engineering Novel CD19/CD22 Dual-Target CAR-T Cells for Improved Anti-Tumor Activity", CANCER INVESTIGATION., TAYLOR & FRANCIS INC., US, vol. 40, no. 3, 25 November 2021 (2021-11-25), US , pages 282 - 292, XP009553897, ISSN: 0735-7907, DOI: 10.1080/07357907.2021.2005798
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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